牙腐烂的随机临床试验是否采用开放科学实践?
Carolina de Picoli Acosta1, Jaisson Cenci2,3, Bruna Brondani1
1Department of Pediatric Dentistry, School of Dentistry, University of São Paulo, Av. Prof. Lineu Prestes 2227., São Paulo, Brazil.
BMC oral health
|November 23, 2024
概括
牙损伤中的开放科学实践 (OSP) 采用随机临床试验 (RCT) 较低,协议注册和报告准则最常见. 然而,近年来,OSP实施的趋势越来越强.
科学领域:
- 牙科研究 牙科研究
- 临床试验 临床试验
- 开放科学是一个开放的科学.
背景情况:
- 开放科学实践 (OSP) 对随机临床试验 (RCT) 的研究完整性和质量至关重要.
- 牙损是一个重大的全球口腔健康挑战,需要高质量的研究,以进行有效的干预.
研究的目的:
- 评估各种开放科学实践 (OSP) 在随机临床试验 (RCT) 中的采用率,重点是牙损伤.
- 确定这一研究领域内OSP采用的趋势和影响因素.
主要方法:
- 在PubMed系统搜索2000年1月至2022年3月期间发表的牙损伤RCT.
- 评估随机抽样的文章,以采用特定的OSP,包括报告准则,协议注册,数据共享和开放访问.
- 使用后勤回归进行了关联分析,考虑了出版年,作者的大陆,期刊影响因子和期刊开放访问政策.
主要成果:
- 超过64%的牙虫试验至少采用了一种OSP,但没有一个OSP超过50%的采用率.
- 协议注册 (37.1%),报告准则 (33.1%) 和开放访问 (37.3%) 是最常采用的OSP.
- 在最近的出版物和研究中观察到更高的采用率,这些研究发表在具有更高影响因素的期刊上.
结论:
- 大多数开放科学实践在牙损伤RCT的整体采用率仍然很低.
- 近年来,越来越多地实施OSP的积极趋势显而易见,与期刊建议保持一致.
更多相关视频
08:20Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries
Published on: March 31, 2021
6.3K
06:16Author Spotlight: Establishing an Accurate Microhardness Testing Protocol for Craniofacial Tissues
Published on: April 26, 2024
622
相关概念视频
01:11Blinding
2.4K
Blinding is a commonly used method of not telling participants which treatment a subject is receiving. Blinding is a critical part of a randomized control trial or RCT. It reduces the bias that affects the results. In an RCT, blinding is used in the form of a placebo. A placebo effect occurs when untreated subjects falsely believe they have received the treatment and report improved symptoms. A placebo or a dummy treatment is administered to subjects to negate the bias caused by such an effect.
2.4K
01:15Teeth
326
The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
326
01:13Randomized Experiments
6.7K
The randomization process involves assigning study participants randomly to experimental or control groups based on their probability of being equally assigned. Randomization is meant to eliminate selection bias and balance known and unknown confounding factors so that the control group is similar to the treatment group as much as possible. A computer program and a random number generator can be used to assign participants to groups in a way that minimizes bias.
Simple randomization
Simple...
Simple randomization
Simple...
6.7K
01:20Study Designs in Epidemiology
182
Epidemiological study designs are fundamental tools for investigating the distribution, determinants, and control of health conditions in populations. They help researchers understand the relationships between exposures and outcomes, and they broadly fall into two categories: "observational" and "experimental" studies.
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and...
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and...
182