在COVID-19感染中,嗅球体积和嗅深度的变化:尸检研究
Sefa Sonmez1, Merve Nur Ozgen1, Sadik Bugrahan Simsek1
1Department of Anatomy, Faculty of Medicine, Tokat Gaziosmanpasa University, Tokat, Turkey.
概括
在尸检病例中,COVID-19显著减少了嗅管球和通道的大小和重量. 这些发现揭示了病毒引起的嗅觉通路的形态变化,影响了嗅觉功能.
科学领域:
- 神经病理学神经病理学
- 传染病病理学 传染病病理学
- 法医医学 法医医学
背景情况:
- COVID-19与神经系统症状有关,包括嗅觉功能障碍.
- 由于COVID-19引起的嗅觉系统的潜在病理生理学和结构变化尚未得到充分理解.
研究的目的:
- 为了调查COVID-19死于COVID-19的个体的嗅觉通路的形态变化.
- 通过验尸数据评估COVID-19对嗅球和嗅道尺寸的影响.
主要方法:
- 一项涉及63例病例 (37例COVID-19,26例对照) 的比较尸检研究,年龄在18-80岁之间.
- 嗅球和气管的形态测量 (尺寸,重量,体积) 用数字标尺,天平和度量筒进行.
- 卷积计算使用了阿基米德的原理.
主要成果:
- 在COVID-19组中观察到双边嗅球 (OB) 和嗅道 (OT) 体积的显著减少 (p < 0.001).
- 在COVID-19组中,OB和OT权重显著较低 (p < 0.001).
- 嗅觉结构的长度,宽度和深度测量在COVID-19病例中显著较短 (p <0.01).
结论:
- 尸体解剖结果显示,COVID-19患者的嗅觉中心内有结构性损伤.
- 了解嗅管球和通道形态对于临床管理和传染病病理学的未来研究至关重要.
相关概念视频
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