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Updated: Jun 6, 2025

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
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作为潜在的抗癌剂的新型皮拉诺-皮里丁合物:设计,合成和计算研究

Aladdin M Srour1, Eman S Nossier2,3, Najla A Altwaijry4

  • 1Department of Therapeutic Chemistry, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Giza, Egypt.

Future medicinal chemistry
|November 24, 2024
PubMed
概括

新的pyranopyridine和pyranopyrimidine化合物对肝脏,乳腺,结肠和肺癌细胞系表现出强大的抗癌活性. 这些新型药物还抑制EGFR和VEGFR-2激酶,表明它们作为向癌症治疗的潜力.

关键词:
欧洲农业基金会 (EGFR) 是一个基金.这是一种Pyrano[3,2-c]pyridine.在VEGFR-2的基础上,这是一种抗癌药物.灭症 (apoptosis) 是一种死亡的过程.

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