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联合伤害 - - 在青少年中常见的外皮表现局部性硬化皮质
M Osminina1, N Podchernyaeva1, L Khachatryan1
1Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Russia.
Georgian medical news
|November 24, 2024
概括
关节病变影响了35%的患有青少年局部性硬皮病 (JLS) 的儿童,特别是线性和单边形式. 自身抗体和纤维化标志物表明活跃的炎症,支持JLS的早期免疫抑制疗法.
科学领域:
- 儿科风湿病学 儿科风湿病学
- 皮肤病学 皮肤病学
- 免疫学 免疫学 免疫学
背景情况:
- 青少年局部性硬化皮肤病 (JLS) 是一种慢性自身免疫性疾病,影响皮肤和结缔组织.
- 在JLS中,关节参与 (JnL) 可能导致显著的发病率.
- 了解JnL的流行和关联对于有效管理至关重要.
研究的目的:
- 为了确定被诊断为青少年局部性硬皮病 (JLS) 的儿童的关节病变 (JnL) 的频率.
- 调查JnL与JLS患者特定自身抗体和纤维化标志物的存在之间的潜在相关性.
主要方法:
- 对500名患有JLS的儿童进行了回顾性分析,通过体检,超声波,X射线和MRI评估关节病变.
- 检测自身抗体,包括抗核因子 (ANF),类风湿性因子 (RF),抗托皮索马酶1抗体,抗中心体抗体,抗dsDNA抗体和抗原抗体 (Cab).
- 在190名患者中测量了纤维化标志物,如晶球蛋白 (CG),纤维素 (FN) 和氨酸 (HA).
主要成果:
- 在35%的JLS患者中发现了关节病变 (JnL),主要是线性 (86%) 和单边形式.
- JnL表现为关节疼痛 (47%) 和有限的运动 (60%),通常是由于纤维化. 超声波检查显示,有45%的病例出现了鼻膜炎.
- 在JnL患者中,更频繁地观察到自抗体 (ANF在56%,RF在28.4%) 和纤维化标志物 (CG,FN,HA,Cab) 的升高水平.
结论:
- 关节病变是JLS的一种常见并发症,发生在35%的病例中,倾向于线性和单边呈现.
- 在患有JnL的儿童中,自身抗体和纤维化标志物的检测增加表明正在进行的自身免疫活动.
- 这些发现支持在JLS患者中考虑早期的全身免疫抑制疗法,这些患者具有关节参与.
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