黑碳颗粒的转移到人类肠道组织
Thessa Van Pee1, Kenneth Vanbrabant1, Leen Rasking1
1Centre for Environmental Sciences, Hasselt University, Agoralaan Building D, 3590, Diepenbeek, Belgium.
EBioMedicine
|November 24, 2024
概括
来自空气污染的黑碳颗粒在人体肠道组织中被发现,包括子粘膜. 这表明空气质量对胃肠道健康有直接影响.
科学领域:
- 环境健康 环境健康
- 胃肠病学 胃肠病学
- 毒理学 毒理学 毒理学
背景情况:
- 越来越多的证据将微粒空气污染,如黑碳,与胃肠道问题和肠道微生物群多样性减少联系在一起.
- 一个潜在的机制涉及通过胃肠道吸收空气污染颗粒.
研究的目的:
- 为了调查黑碳颗粒在人类肠道组织中的存在和分布.
- 提供关于空气污染被肠道吸收的证据.
主要方法:
- 分析了五名人类患者的骨髓和结肠活检.
- 黑碳颗粒的可视化和量化,使用秒脉冲激光诱导的白光生成.
- 对粘膜层,粘膜下层和肌肉自身层中的颗粒生物分布的评估.
主要成果:
- 在三层组织层中都检测到黑碳颗粒,无论是大肠和结肠活检.
- 与粘膜和肌肉本身相比,在粘膜下观察到更高的黑碳负载.
- 一个趋势表明,大肠内比结肠内有更高的黑碳度,主要是由于粘膜下积累.
结论:
- 这项研究提供了人类肠道组织层中黑碳颗粒的第一个直接证据.
- 这些发现支持了吸入空气污染颗粒物可以转移到肠道的假设.
- 需要进一步的研究,以了解微粒空气污染对胃肠道健康的直接影响.
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