动脉化体积与Pseudoxanthoma elasticum中心血管事件的风险更高有关
Iris M Harmsen1, Frank L J Visseren1, Madeleine Kok2
1Department of Vascular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
Atherosclerosis
|November 24, 2024
概括
在pseudoxanthoma elasticum (PXE) 中,CT扫描上较高的动脉化预测了以前没有心血管病史的患者未来的心血管事件. 这一发现支持将动脉化作为临床试验的终点.
科学领域:
- 血管医学 血管医学
- 遗传学 是一个遗传学.
- 放射学 放射学是一门学科.
背景情况:
- 伪黄弹性 (PXE) 与动脉化有关,原因是ABCC6基因突变,但其与血管并发症的关联尚不清楚.
- 对于临床试验,PXE疾病进展需要可靠的中间终点.
- 计算机断层扫描 (CT) 上的动脉化是PXE中心血管事件的潜在替代标记物.
研究的目的:
- 确定CT测量的动脉化与PXE患者未来心血管事件之间的关系.
主要方法:
- 一项前性队列研究包括来自UMC乌得勒支PXE专家中心 (UECP) 的326名PXE患者.
- 使用低剂量全身CT扫描量化动脉化体积.
- 考克斯的比例危险模型分析了动脉化和心血管事件之间在6.0年的中位数随访期间的关联.
主要成果:
- 发生了41次心血管事件 (每1000人年21次).
- 在没有先前心血管病史的PXE患者中,在基线时增加的动脉化体积与未来心血管事件有显著的相关性 (调整HR:1.87).
- 在患有先前心血管疾病的患者中,动脉化和未来事件之间没有发现显著的关联.
结论:
- 在PXE患者的CT扫描中,动脉化升高表明第一个心血管事件的风险增加.
- 在PXE临床研究中,动脉化显示为评估旨在降低心血管风险的干预措施的中间终点.
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