相关实验视频

Updated: Jun 6, 2025

Anti-Nuclear Antibody Screening Using HEp-2 Cells

Anti-Nuclear Antibody Screening Using HEp-2 Cells

Published on: June 23, 2014

防晒的使用与美国成年人中抗核抗体的患病率增加有关

Christine G Parks¹, Todd A Jusko², Helen C S Meier³

¹Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, 27709, USA.

Journal of autoimmunity

|November 24, 2024

概括

经常使用防晒与年轻人的抗核抗体 (ANA) 有关. 需要进一步的研究来证实防晒和ANA之间的这种关联.

科学领域:

环境健康环境健康
免疫学免疫学免疫学
皮肤病学皮肤病学

背景情况:

反核抗体 (ANA) 的流行率在美国人口中增加.
之前的研究将ANA与防晒成分索-3的尿液水平联系起来,但点滴尿液测试可能不会反映慢性暴露.
这项研究调查了ANA和报道的防晒使用之间的关系.

研究的目的:

检查抗核抗体 (ANA) 患病率与自我报告的防晒使用之间的关联.
探索潜在的混或改变因素,包括年龄,性别,种族/民族,季节,维生素D水平和其他防晒行为.

主要方法:

一项横截面研究分析了416名ANA阳性和2656名ANA阴性成年人 (20-59岁) 的数据.
通过逻辑回归来评估ANA和防晒使用之间的关联,计算调整的流行概率比率 (POR) 和95%置信区间 (CI).
分析根据人口因素,季节和维生素D状况进行了分层,并探索了与其他防晒行为和晒伤史的相互作用.

主要成果:

防晒的使用显示出与ANA的年龄相关联 (相互作用p=0.004).
在年轻的成年人中 (20-39岁),频繁使用防晒与增加的ANA患病率有关 (POR 2.61总是/大部分时间).
在女性,非西班牙裔白人和黑人以及具有足够维生素D水平的人群中,这种关联更为明显.

结论:

频繁使用防晒与年轻人中的ANA有关.
这些发现支持需要复制和纵向研究,并进行详细的暴露评估.
该研究强调了防晒使用和ANA之间的潜在联系,特别是在特定的人口群体中.

关键词:

抗核抗体是一种抗核抗体.这是一种自身免疫力.跨截面研究是跨截面研究.氧基松是一种氧基素.太阳灼伤是因为太阳灼伤.防晒可以防晒.

更多相关视频

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

Published on: September 7, 2013

Simultaneous Distinction of Monospecific and Mixed DFS70 Patterns During ANA Screening with a Novel HEp-2 ELITE/DFS70 Knockout Substrate

Simultaneous Distinction of Monospecific and Mixed DFS70 Patterns During ANA Screening with a Novel HEp-2 ELITE/DFS70 Knockout Substrate

Published on: January 17, 2018

相关概念视频

Mutations

Mutations

Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...

Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

Nucleotide Excision Repair

Nucleotide Excision Repair

DNA Distortion and Damage
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...

Cancer Prevention

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...