基于磁活性弹性体的动态尿道支装置用于应激性尿失禁.
Seelay Tasmim1, Asha Baten1, Manivannan Sivaperuman Kalairaj1
1Texas A&M University, Department of Biomedical Engineering, College Station, TX, United States.
Acta biomaterialia
|November 24, 2024
概括
一种新的磁活性弹性体吊带动态调整尿道支以治疗压力尿失禁 (SUI). 这种外部控制的设备为传统的SUI治疗提供了一个有希望的,不那么侵入性的替代方案.
科学领域:
- 生物材料科学 生物材料科学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 医疗器械 医疗器械
背景情况:
- 压力尿失禁 (SUI) 影响了许多成年女性,目前的吊带治疗缺乏调节性.
- 现有的可调节设备往往涉及侵入性手术或复杂的组件.
研究的目的:
- 设计和评估软磁活性弹性体 (MAE) 装置,用于SUI治疗中可调节的尿道支.
- 在模拟下尿道模型中评估MAE设备的形状变化能力和性能.
主要方法:
- 嵌入MAE设备在不同的刚度的凝中,以测试磁场 (高达200mT) 下的形状变化.
- 实验室下尿道模型被用于测量MAE吊带激活前后的流量时间和膀压力.
- 在加速的氧化和水解条件下评估了设备的稳定性.
主要成果:
- 在100kPa的阿加凝中,MAE装置显示高度变化为4.7%±1.1%.
- 涂MAE设备的质量损失最小 (2.36%±1.55%氧化,0.58%±0.25%水解).
- 在60厘米-H2O时,MAE吊带显著减少了正常流量时间,从1.56±0.18减少到1.11±0.16,显示可调节的尿道支.
结论:
- 一个动态的,磁性控制的MAE套筒可以调节尿道支在下尿道模型.
- 这种概念验证设备为SUI提供了不那么侵入性的,可调节的治疗方法,有可能预防并发症并改善患者的生活质量.
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