拉曼光谱中的补充硬模拟:对无二氧化涂层在线监测的案例研究
René Brands1, Jens Bartsch1, Markus Thommes1
1Laboratory of Solids Process Engineering, Department of Biochemical and Chemical Engineering, TU Dortmund University, 44227 Dortmund, Germany.
Journal of pharmaceutical sciences
|November 24, 2024
概括
碳酸盐涂层在药片上提供了替代二氧化的替代品. 补充硬模拟 (CHM) 有效地监控涂层过程,甚至在有限的数据上也超过传统方法.
科学领域:
- 制药技术 制药技术 制药技术
- 材料科学是一种材料科学.
- 分析化学是一种分析化学.
背景情况:
- 药片涂层有多种用途,包括掩盖味道,修改释放和增强稳定性.
- 二氧化是一种常见的不透明涂料剂,具有用于线内监测的Raman活性.
- 由于对二氧化致癌性的担忧,需要更安全的替代品,如碳酸.
研究的目的:
- 评估碳酸作为不透明的涂料剂,并开发平板涂料工艺的线性监测模型.
- 为了比较部分最小平方回归 (PLS) 和补充硬模型 (CHM) 的性能,用于监测碳酸涂层.
- 评估不同测量位置在涂层器内对监测模型性能的影响.
主要方法:
- 药片被涂层使用含有碳酸的配方.
- 在线监测使用拉曼光谱进行.
- 部分最小平方回归 (PLS) 和补充硬模型 (CHM) 用于数据分析.
- 研究了两个测量位置 (直角和触角).
主要成果:
- 补充硬建模 (CHM) 与PLS相比表现有所改善,交叉验证的根平均平方误差 (RMSECV) 减少了5%.
- 涂层质量增长预测在方法之间是可比的,根平均平方预测误差 (RMSEP) 值在2-5%之间.
- 随着培训数据数量和质量的减少,CHM表现得更好.
- 在直角和触角测量位置之间没有观察到与过程相关的显著差异.
结论:
- 碳酸是二氧化可行的替代品,用于平板电脑涂层,提供类似的不透明度.
- 补充硬模拟 (CHM) 是一种强大而有效的方法,用于在线监测平板电脑涂层过程,特别是当数据有限时.
- 涂层器内的测量位置不会显著影响开发的监测模型的有效性.
相关概念视频
01:20Raman Spectroscopy: Overview
309
The underlying principle of Raman spectroscopy is based on the interaction between light and matter, specifically molecules' inelastic scattering of photons. When a monochromatic beam of light, typically from a laser source, interacts with a sample, most scattered light has the same frequency as the incident light. This is known as Rayleigh scattering.
However, a small fraction of the scattered light exhibits a frequency shift due to the exchange of energy between the incident photons and...
However, a small fraction of the scattered light exhibits a frequency shift due to the exchange of energy between the incident photons and...
309
01:26Raman Spectroscopy Instrumentation: Overview
296
A conventional Raman spectrophotometer includes a laser source, a sample holding system, a wavelength selector, and a detector.
The monochromatic laser source, typically using visible or near-infrared radiation, generates a highly focused beam of light. This light interacts with the molecules of the sample, scattering some of the light. Liquid and gaseous samples are usually tested in ordinary glass capillaries, while solids can be analyzed as powders packed in capillaries or as potassium...
The monochromatic laser source, typically using visible or near-infrared radiation, generates a highly focused beam of light. This light interacts with the molecules of the sample, scattering some of the light. Liquid and gaseous samples are usually tested in ordinary glass capillaries, while solids can be analyzed as powders packed in capillaries or as potassium...
296