阿尔茨海默病的疾病修饰疗法:临床试验进展和机会
Yujie Zhang1, Jie Chen2, Yanru Li2
1Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, PR China; Xiangya School of Medicine, Central South University, Changsha 410013, PR China.
Ageing research reviews
|November 24, 2024
概括
新的阿尔茨海默病 (AD) 治疗方法,包括lecanemab和donanemab,提供了希望. 本综述探讨了AD的多种疾病修饰疗法 (DMT),包括药物,大脑刺激和生活方式改变.
科学领域:
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
- 老年学是一门学科.
背景情况:
- 阿尔茨海默病 (AD) 带来了巨大的财务和人力成本.
- 最近FDA对lecanemab和donanemab的批准为疾病修饰疗法 (DMT) 提供了新的希望.
- 许多其他DMT正在开发中,以满足AD治疗需求.
研究的目的:
- 对阿尔茨海默病的各种疾病修饰疗法 (DMT) 进行审查.
- 分析各种候选药物,大脑刺激和生活方式干预的临床试验进展.
- 为未来的AD DMT方法提供见解,重点关注普遍性和经济可行性.
主要方法:
- 关于AD DMTs的综合文献综述.
- 对正在进行,已完成和已停止的候选药物的临床试验数据的分析.
- 在审查中包括大脑刺激和生活方式干预措施.
主要成果:
- 莱卡尼马布和多纳尼马布代表了抗粉样β单克隆抗体治疗的重大进展.
- 包括小分子和生物制剂在内的广泛的DMT候选药物已经或正在进行临床试验.
- 脑刺激和生活方式干预也被探索为AD补充或替代治疗.
结论:
- 阿尔茨海默病治疗的景观正在迅速发展,有新的治疗选择.
- 未来的研究应该专注于优化DMT的疗效,普遍性和经济可用性,以获得更广泛的患者利益.
- 结合药理和非药理干预的多方面的方法可能是有效管理阿尔茨海默病的关键.
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