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怀孕早期母亲的异常肝功能和自发的怀孕损失:一个回顾性队列研究

Huibin Yang¹, Tianyi Tang², Qianlei Qian³

¹Minhang Maternal and Child Health Hospital.

Journal of epidemiology

|November 24, 2024

概括

孕妇在怀孕早期的肝功能异常,包括高马-胺转移酶 (GGT) 和性酸酶 (ALP),显著增加了自发妊娠损失 (SPL) 的风险. 这一发现强调了监测早期产前护理期间肝脏健康的重要性,以减少SPL发病率.

科学领域:

产科和妇科产科和妇科
肝病学肝病学是一种肝病学.
生殖医学生殖医学

背景情况:

自发流产 (SPL) 是一种常见的并发症,主要原因不明.
怀孕早期的肝功能障碍可能表明已经存在的影响胎儿发育的疾病.
研究母亲肝功能和SPL之间的联系对于理解生殖健康结果至关重要.

研究的目的:

为了确定在怀孕早期母亲的异常肝功能是否与自发流产 (SPL) 的风险增加有关.
为了确定特定的肝功能生物标志物,可以预测SPL风险.
为早期查和干预策略提供证据.

主要方法:

利用了上海妇产保健信息系统 (2017-2021) 的数据.
在第一个产前检查时,通过肝功能生物标志物 (LFBs) 的升高来确定肝功能障碍.
采用了通用线性模型来计算SPL的风险比率 (RR) 和调整的风险比率 (aRR).

主要成果:

一组由10,175名孕妇组成的队列产生了918 (9.0%) SPL病例.
孕产妇的肝功能障碍与SPL风险增加49%有关 (aRR为1.55;95% CI为1.26-1.92).
高的马-氨基转移酶 (GGT) 和性酸酶 (ALP) 与增加的SPL风险呈现线性关联.

结论:

怀孕早期母亲的肝功能异常是自发流产的重要危险因素.
特定的生物标志物,GGT和ALP,与SPL的更高风险有关.
这些发现强调了在早期产前护理期间评估肝功能的重要性.

关键词:

队列研究是一项队列研究.怀孕早期的怀孕早期的怀孕肝脏酶水平的水平是什么肝功能肝功能肝功能自发的怀孕流产.

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