在Sjogren病中基于症状的亚型的稳定性
Joe Scott Berry1,2, Jessica Tarn1, John Casement3
1Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, Tyne and Wear, UK.
RMD open
|November 24, 2024
概括
对于大多数患者来说,基于症状的Sjogren病亚型 (使用纽卡斯尔Sjogren的分层工具) 随着时间的推移是稳定的. 这种稳定性支持它们在临床试验和患者管理中的使用.
科学领域:
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
- 临床试验 临床试验
背景情况:
- 纽卡斯尔斯乔格伦分层工具 (NSST) 将斯乔格伦病患者分为四种亚型.
- 了解这些基于症状的亚型的纵向稳定性对于它们更广泛的临床采用至关重要.
研究的目的:
- 评估NSST定义的Sjogren病亚型在时间上的稳定性.
- 确定影响亚型分类变化的因素.
主要方法:
- 来自英国初级Sjögren综合征登记处 (UKPSSR) 的274名患者的纵向分析.
- 使用法国ASSESS队列 (n=237) 的验证.
- 使用后勤回归模型来确定亚型稳定性的预测因素.
主要成果:
- 亚型成员表现出合理的稳定性,60% (UKPSSR) 和57% (ASSESS) 的患者保留了他们的亚型.
- 高症状负担亚型表现出最高的稳定性 (70%的UKPSSR,67%的ASSESS).
- 较高的基线概率得分,C4水平,抗抑郁药使用和CCI得分预测了亚型稳定性的增加.
结论:
- 根据NSST的定义,Sjogren病亚型的成员在长度上基本稳定.
- 亚型转换最多与不确定的基线分配有关.
- 这些发现支持在临床试验设计和管理中使用这些基于症状的亚型作为潜在的病理生物学内型.
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