与SLE认知变化相关的结构和功能同位素连接的改变.
Sha Ni1, Ning An1, Chunlei Li2
1Inner Mongolia Medical University, Hohhot, Inner Mongolia, China.
Lupus science & medicine
|November 24, 2024
概括
系统性红斑狼 (SLE) 患者在胰岛和副海马圈中显示出大脑连接和结构的改变. 这些变化与认知缺陷和狼特异性抗体相关.
科学领域:
- 神经成像是一种神经成像.
- 神经学 神经学
- 类风湿病学 类风湿病学
背景情况:
- 以前的研究表明,系统性红斑狼 (SLE) 患者的功能性大脑变化.
- 在SLE中,半球间大脑变化仍未得到充分研究.
研究的目的:
- 用fMRI研究SLE患者的功能和结构半球间变化.
- 为了将这些大脑变化与认知功能和临床标志物相关联.
主要方法:
- 54名SLE患者和32名健康对照 (HCs) 接受了MRI和神经心理测试.
- 分析了voxel镜像同位素连接 (VMHC) 和灰色物质体积.
- 相关性分析检查了成像数据,认知和生化标志物之间的关系.
主要成果:
- 与HC患者相比,SLE患者在胰岛和副海马环中表现出增加的VMHC.
- 在这些相同的区域中,在SLE患者中观察到灰质体积减少.
- 岛内VMHC增加与定位和注意力受损相关;灰质减少与注意力和抽象缺陷相关. 两者都与狼抗体有关.
结论:
- 胰岛和副海马环中的结构和功能变化可能作为SLE的神经成像生物标志物.
- 与狼相关的抗体可能在SLE相关的大脑功能障碍中发挥作用.
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