怀疑早产对胎儿心血管和代谢编程的影响:一个前性队列研究协议
Natalia Abadía-Cuchí1, Marcos Clavero-Adell2,3, Jesús González4
1Obstetrics and Gynaecology, Hospital Clinico Universitario Lozano Blesa, Zaragoza, Spain.
BMJ open
|November 24, 2024
概括
怀疑过早分娩 (SPL) 可能会影响后代的心血管和代谢健康,即使是按期分娩. 这项研究调查了SPL对心脏重塑和代谢编程的长期影响.
科学领域:
- 产科和妇科 产科和妇科
- 围产儿医学 围产儿医学
- 发育儿科 发育儿科
背景情况:
- 怀疑过早分娩 (SPL) 影响了9%的怀孕,是住院的主要原因.
- 虽然早产是后来心血管和代谢疾病的已知危险因素,但SPL对按时出生的婴儿的影响不太清楚.
- 新出现的证据表明,即使在预期分娩的情况下,SPL也会产生长期影响,因此需要进一步调查心血管和代谢编程.
研究的目的:
- 评估疑似早产 (SPL) 对心脏重塑和功能的影响.
- 评估SPL对后代心血管和代谢特征的影响.
- 为了独立于出生时的妊娠年龄来确定这些影响.
主要方法:
- 前性队列研究,比较有SPL和没有SPL的怀孕.
- 在SPL入院期间和产后6个月时进行胎儿心声扫描.
- 对代谢足迹和心血管/代谢风险生物标志物的带血分析.
- 多变量建模以考虑社会经济因素,围产期特征,生活方式,饮食和运动等共变量.
主要成果:
- 当研究完成并可获得结果后,该部分应填写.
结论:
- 当研究完成并可获得结果后,该部分应填写.
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