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代谢和减肥手术与恶性瘤之间的关联:系统审查,元分析,趋势和结论
Libi-Or Madar1, Nitzan Goldberg2, Uri Netz1
1Department of Surgery A, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
概括
与非手术治疗相比,代谢和减肥手术 (MBS) 显著降低了肥胖患者的整体癌症风险. 此外,MBS还显示出对某些癌症的保护作用,如结肠直肠癌,子宫癌,乳腺癌和食道癌.
科学领域:
- 医学研究 医学研究
- 在瘤学瘤学.
- 手术方面的创新.
背景情况:
- 关于肥胖,代谢和减肥手术 (MBS) 和癌症风险之间的关系存在相互矛盾的研究.
- 肥胖是各种恶性瘤的已知危险因素.
研究的目的:
- 分析与肥胖相关的癌症发病率趋势和通过MBS实现的体重减轻.
- 研究MBS对特定癌症的影响,包括结肠直肠癌,乳腺癌,子宫癌和食道癌.
主要方法:
- 按照PRISMA指南进行了系统审查和元分析.
- 到2020年5月,在PubMed,Embase和Cochrane图书馆数据库中进行了搜索.
- 包括的研究分析了各种MBS程序,如袖子胃切除术,胃绕道和胃带.
主要成果:
- 分析包括21项研究,显示MBS后与肥胖个体的非手术治疗相比,整体癌症风险降低 (平均效果大小: -0.33).
- MBS表明对结直肠 (平均ES) 有保护作用. -0.28),子宫 (E.S. 的平均值). -0.42),乳房 (平均E.S. -0.42),乳房 (平均E.S. -0.42),乳房 (平均E.S. -0.42),乳房 (平均E.S. -0.42),乳房 (平均E.S. -0.42),乳房 (平均E. -0.37),食道癌 (平均ES) 和食道癌. -0.23) 的情况.
- 虽然观察到趋势,但没有检测到肝脏,胰腺和皮肤癌发病率的显著变化.
结论:
- 接受MBS治疗的患者与非手术治疗的肥胖患者相比,患恶性瘤的总体风险较低.
- 通过MBS诱导的减肥积极影响特定的与肥胖有关的癌症的发生率.
- MBS的好处超越了改善与肥胖相关的并发症,影响癌症风险降低.
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