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S1P/S1PRs-TRPV4轴是慢性皮肤炎中持续疼痛和的新型治疗点

Xinyu Zhang1,2, Yuan Zhou2, Changming Wang2

  • 1Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Jiangsu Key Laboratory for High Technology Research of TCM Formulae, Nanjing University of Chinese Medicine, Nanjing, China.

British journal of pharmacology
|November 24, 2024
PubMed
概括

慢性皮肤炎 (CD) 中的基-1-酸盐 (S1P) 增加会通过TRPV4.4引起疼痛和. 抑制S1P合成为CD相关症状提供了一个有前途的治疗策略.

关键词:
在S1P中,它是S1P.在 TRPV4 中.慢性皮肤炎 慢性皮肤炎一个,一个,一个.疼痛 疼痛 疼痛 疼痛

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Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
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