哺乳期母卵消费与12个月大的婴儿患蛋过敏的风险之间的关系:一个多中心队列研究
Sakurako Kishino1, Kaori Yonezawa1,2, Megumi Haruna1,2
1Division of Health Sciences and Nursing, Department of Midwifery and Women's Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Japan journal of nursing science : JJNS
|November 24, 2024
概括
哺乳期母亲的蛋消费并没有防止婴儿的蛋过敏. 然而,六个月的婴儿湿疹使得12个月的患蛋过敏的风险增加了.
科学领域:
- 儿科过敏和免疫学
- 营养免疫学 营养免疫学
- 孕产妇和婴儿的健康
背景情况:
- 婴儿蛋过敏是一个越来越大的问题,早期的生命暴露可能会影响免疫耐受性.
- 据假设,哺乳期母亲的饮食摄入量会影响婴儿的免疫发育和过敏风险.
研究的目的:
- 调查母乳养期间母卵消费对12个月龄婴儿卵过敏发展的影响.
- 为了确定增加母卵摄入量是否促进婴儿口服免疫耐受性.
主要方法:
- 一项涉及420对母婴对的队列研究,来自日本怀孕饮食和活动队列研究.
- 通过问卷来评估母亲的蛋消费和婴儿的结果 (湿疹,蛋过敏).
- 计算了依赖母乳养的蛋消费量,以评估母乳摄入对婴儿的影响.
主要成果:
- 在依赖母乳养的母乳蛋消费和12个月的婴儿蛋过敏发展之间没有发现显著的关联.
- 在6个月时被诊断患有湿疹的婴儿在12个月时患蛋过敏的风险显著增加 (aOR3.59).
结论:
- 在哺乳期早期,母亲的蛋消费似乎没有赋予足够的口服免疫耐受性,以防止婴儿的蛋过敏.
- 6个月的婴儿湿疹是产生卵子过敏的重要危险因素,强调了管理皮肤屏障功能的重要性.
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