在酵素过程中从批量到连续流合成向Molnupiravir.
Siriwat Hongnak1, Onanong Vorasin1, Pornthip Aunbamrung1
1National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), Pathum Thani, Thailand.
Chemistry, an Asian journal
|November 24, 2024
概括
使用两步批量和连续流生物催化剂,改善了molnupiravir的合成. 这种方法提高了治疗COVID-19的效率和生产力,提供了可持续的工业生产路线.
科学领域:
- 生物催化和有机合成
- 药用化学和药物开发 医学化学和药物开发
- 化学工程和工艺优化 化学工程和工艺优化
背景情况:
- 莫尔努皮拉维尔是COVID-19治疗的关键抗病毒药物.
- 由于COVID-19的流行,需要快速开发高效的药物合成方法.
- 现有的molnupiravir合成途径需要优化,以适应大规模生产.
研究的目的:
- 开发一种容易,可扩展和高效的molnupiravir合成方法.
- 实施连续流生物催化剂以提高生产效率.
- 为了比较molnupiravir合成的批量和连续流过程.
主要方法:
- 一个两步合成,涉及转氨基化cytidine和区域选择性化.
- 使用固定脂酶和异黄油化物进行化.
- 实现了批处理和连续流生物催化.
主要成果:
- 通过批量加工实现了48%的总产量和99.98%的纯度.
- 连续流生物催化剂证明了可比的产量和纯度.
- 连续流提供了显著的优势:2.42倍更高的生产率,2.47倍更快的反应时间和30倍更高的时空收益率.
结论:
- 优化的批量和连续流生物催化提高了molnupiravir合成效率.
- 连续流生物催化剂是一种更具生产力和时间效率的方法.
- 这些优化的流程为工业molnupiravir生产提供了一种可持续的方法,可以减少对环境的影响.
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