识别轻度认知障碍和痴呆症老年人多变量认知变化的快速参考标准:一项ADNI研究
Jeremy G Grant1,2, Amanda M Wisinger2, Hilary F Abel2
1Department of Psychology, The Ohio State University, Columbus, OH, USA.
Journal of the International Neuropsychological Society : JINS
|November 24, 2024
概括
对于老年人来说,多重神经心理测试得分显著下降是不常见的. 较多的下降分数可能表明老年人的异常认知变化.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 认知心理学 认知心理学
背景情况:
- 评估老年人的认知变化对于早期发现神经退行性疾病至关重要.
- 建立认知衰退的规范性数据对于准确的诊断至关重要.
研究的目的:
- 确定老年人的神经心理测量中统计学上罕见的变化标准.
- 在健康老龄化人口中确定显著认知衰退的门.
主要方法:
- 利用了来自阿尔茨海默病神经成像计划两年来935名老年人的数据.
- 在使用认知正常参与者的七项认知措施中确定了变化得分的第五百分点值.
- 在认知正常,轻度认知障碍 (MCI) 和痴呆症组中分析了下值变化得分的数量.
主要成果:
- 只有4.2%的认知正常人有两个或两个以上的分数低于第五百分点值.
- 转换为痴呆症的人中有38.6%的人表现出两个或两个以上低于值的变化得分.
- 低于值的变化得分数量显著预测了诊断组成员资格,即使经过对共变量进行调整.
结论:
- 在七个测试的神经心理学电池中经历两种或更多的统计学上罕见的变化在老年人中并不常见.
- 显著认知衰退的较高数量可能作为非典型认知衰老或发展为痴呆症的指标.
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