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益生菌对妊娠期糖尿病的影响:一个总体的元分析
Guixia Sun1, Hongli Hou2, Shanshan Yang2
1Department of Gynecology and Obstetrics, Shanxi Provincial Children's Hospital (Shanxi Provincial Maternal and Child Health Hospital), No.13 Xinmin North Street, Taiyuan, Shanxi, 030001, China. sgx8647@126.com.
BMC endocrine disorders
|November 24, 2024
概括
益生菌在改善孕期糖尿病 (GDM) 妇女的血糖控制方面表现有希望. 虽然对禁食血糖的影响没有临床意义,但益生菌显著改善了胰岛素抵抗和β细胞功能.
科学领域:
- 内分泌学和新陈代谢学
- 微生物组研究 微生物组研究
- 孕产妇健康 孕产妇健康
背景情况:
- 以前的研究表明,益生菌对妊娠糖尿病 (GDM) 的血糖调节有好处.
- 现有证据是不确定的,需要进一步调查.
- 这项研究旨在澄清益生菌对GDM血糖指标的影响.
研究的目的:
- 进行一项总体元分析,评估益生菌对GDM血糖指标的影响.
- 综合现有随机临床试验元分析的发现.
主要方法:
- 我们对PubMed和Scopus数据库进行了系统的搜索,搜索到2024年7月发布的元分析.
- 评估的关键血糖指标包括HbA1c,空腹血糖 (FBS),空腹血胰岛素 (FBI),HOMA-IR,QUICKI,HOMA-B,C-和OGTT.
- 使用标准化平均差异 (SMD) 来分析这些影响.
主要成果:
- 该分析包括27个元分析,共33378名参与者.
- 益生菌显著减少了FBS,FBI,HOMA-IR和HOMA-B,并改善了QUICKI.
- 没有发现对HbA1c,C-或OGTT结果的显著影响;注意到异质性和出版偏差.
结论:
- 益生菌补充剂可以增强患有GDM的女性的血糖控制.
- 在胰岛素耐药性 (HOMA-IR),β细胞功能 (HOMA-B) 和禁食胰岛素方面观察到临床显著的改善.
- 对禁食血糖 (FBS) 的影响不被认为具有临床意义.
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