异原子合的磁性光碳点,是多式联络成像的有力剂
Abolghasem Abbasi Kajani1, Ali Pouresmaeili2, Masoud Ayatollahi Mehrgardi3
1Department of Biotechnology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, 81746-73441, Iran. agh.abbasi@bio.ui.ac.ir.
Scientific reports
|November 24, 2024
概括
研究人员使用葡萄糖开发了光和磁性碳点 (CD) 的绿色合成方法. 和的兴奋剂增强了它们的特性,使得有效的细胞成像和体内瘤可视化成为可能.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术 纳米技术
- 生物医学工程 生物医学工程
背景情况:
- 碳点 (CD) 是具有独特光学和电子特性的纳米材料.
- 为功能CD开发绿色和高效的合成方法对于其应用至关重要.
- 现有的方法往往缺乏对光和磁性等属性的控制.
研究的目的:
- 开发一种简单的,单的,绿色的热水法,用于合成高光和磁性碳点 (CD).
- 调查和异构原子兴奋剂对CD光学和磁性特性的影响.
- 评估合成的CDs在体外细胞成像和体内瘤成像中的潜力.
主要方法:
- 使用D-葡萄糖作为碳源的热水合成.
- 使用m-phenylenediamine (mPDA) 的兴奋剂和使用金属硫酸盐 (例如,MnSO4) 的异构原子兴奋剂.
- 使用UV-Vis,光谱学,DLS,FTIR,TEM,EDS,XRD和VSM进行表征.
- 在人体纤维细胞和内皮细胞的体外细胞成像.
- 在小鼠瘤模型的体内MRI和光成像.
主要成果:
- 通过绿色方法成功合成了高光和磁性碳点 (CD).
- 兴奋剂,特别是mPDA,显著增强了光量子产量 (QY).
- ,硫和联合合的CD显示多色光 (QYs高达53.9%) 和高r1放松性 (32.3mM-1s-1).
- 磁盘显示了快速吸收,高质量的成像和低毒性在体外.
- 使用MR和光模式的体内瘤成像显示了高对比度.
结论:
- 开发的单绿色合成为多功能光和磁性CD提供了一条有效的途径.
- 配合和的配合剂优化了CD特性,用于先进的生物成像应用.
- 这些CD对双模体体外和体内成像具有极小的毒性具有重大前景.
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