选择性外科住院患者中与药物相关的问题:一项回顾性研究
Clara Simon1, Olaf Rose1, Karin Kanduth1
1Institute of Pharmacy, Pharmaceutical Biology and Clinical Pharmacy, Paracelsus Medical University Salzburg, Salzburg, Austria.
Science progress
|November 25, 2024
概括
选择性手术患者的药物相关问题不常见,但在临床上是显著的,通常涉及药物相互作用和超治疗剂量. 识别这些问题对于患者安全至关重要.
科学领域:
- 药物监督 药物监督 药物监督
- 外科手术患者的安全
- 药物相互作用研究 药物相互作用研究
背景情况:
- 与药物相关的问题 (DRPs) 在手术患者中对外科手术后并发症存在重大风险.
- 了解选择性外科住院患者中DRP的患病率和特征对于降低风险至关重要.
研究的目的:
- 确定DRP的患病率,数量,特征,临床意义和涉及的药物在选择性外科住院患者中.
- 评估患有DRPs的患者的并发症负担.
主要方法:
- 在九个手术场所进行了回顾性观察性研究.
- 纳入标准:选择性手术,≥1 DRP,≥24h住院时间,年龄≥18岁.
- 使用的分类系统:欧洲制药网V9.1,哈托姆尺度,解剖治疗化学 (ATC),查尔森并发症指数.
主要成果:
- 对11176名住院患者中的284名患者的分析显示,DRP患病率为9.89% (平均每名患者1.43个DRP).
- 主要原因:药物相互作用 (30.3%) 和超治疗剂量 (18.0%).
- 82%的DRP具有临床意义;心血管药物经常涉及. 常见的并发病包括癌症,糖尿病导致末端器官损伤,以及外周血管疾病.
结论:
- 尽管患病率低,但由于其原因和临床影响,选择性手术患者的DRP具有重要意义.
- 患有DRP的患者表现出中度的并发症负担.
- 需要识别和管理患有DRP风险的患者,以加强外科手术期间的护理.
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