尼尔西维玛布治疗婴儿和幼儿呼吸道结囊病毒的成本效益
David W Hutton1, Lisa A Prosser1,2, Angela M Rose2
1Department of Health Management and Policy, School of Public Health.
Pediatrics
|November 25, 2024
概括
尼尔西维玛是预防婴儿呼吸道同胞病毒 (RSV) 住院治疗的经济有效选择. 它具有显著的价值,特别是在高风险婴儿和RSV相关成本较高的场景中.
科学领域:
- 公共卫生 公共卫生
- 卫生经济学 卫生经济学
- 儿童传染病 儿童传染病
背景情况:
- 呼吸道同胞病毒 (RSV) 是美国婴儿住院的主要原因.
- 尼尔西维马布建议在RSV第一季的婴儿和第二季的高风险儿童服用.
- 评估nirsevimab的成本效益对于公共卫生政策至关重要.
研究的目的:
- 评估nirsevimab在RSV第一季的所有婴儿的成本效益.
- 评估nirsevimab在第二个RSV季节高风险儿童的成本效益.
- 分析社会结果,并确定对nirsevimab的成本效益有影响的因素.
主要方法:
- 使用模拟模型估计医疗保健利用率和RSV死亡率.
- 数据来源于已发表的文献,FDA文件和监视数据.
- 社会结果被评估为终身,使用3%的折扣.
主要成果:
- 平均每年有107,253次门诊,38,204次急诊和14,341次住院治疗,如果一半的分娩队伍接受nirsevimab.
- 成本效益是第一个季节为nirsevimab节省的每QALY153,517美元.
- 成本效益为308,468美元,每QALY节省了第二季的高风险儿童.
结论:
- 尼尔塞维马布是针对RSV的婴儿潜在的成本效益干预措施.
- 具有较高RSV风险和相关医疗保健成本的人群中,成本效益特别有利.
- 敏感性分析证实了成本效益的关键驱动因素,包括RSV住院费用和nirsevimab的价格.
更多相关视频
相关概念视频
Drugs Used in Lower Respiratory Disorders: Overview
352
Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
352
Common Respiratory Disorders
310
Respiratory disorders, a prevalent health concern globally, are generally divided into two primary categories: upper and lower respiratory tract disorders. The categorization is based on the area of the respiratory system they affect.
Upper respiratory disorders impact the airways above the vocal cords, encompassing areas like the nose, sinuses, and throat. Various conditions fall under this category, including the common cold and allergic rhinitis. These disorders can stem from several causes,...
Upper respiratory disorders impact the airways above the vocal cords, encompassing areas like the nose, sinuses, and throat. Various conditions fall under this category, including the common cold and allergic rhinitis. These disorders can stem from several causes,...
310
Acute Respiratory Failure-II
174
Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
174
Acute Respiratory Failure-I
173
Acute respiratory failure is a condition characterized by the inability of the lungs to perform their primary function: gas exchange. This failure leads to insufficient oxygen levels (hypoxemia) in the blood, elevated carbon dioxide levels (hypercapnia), or both, causing critical impairment in organ function.
Definition: It is defined by specific criteria based on blood gas measurements. Hypoxemia happens when the partial pressure of oxygen (PaO2) falls below 60 mmHg. At the same time,...
Definition: It is defined by specific criteria based on blood gas measurements. Hypoxemia happens when the partial pressure of oxygen (PaO2) falls below 60 mmHg. At the same time,...
173
Acute Respiratory Failure-V
123
The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
Ensure that patients are monitored continuously for their response to therapy, including changes in...
Ensure that patients are monitored continuously for their response to therapy, including changes in...
123
Acute Respiratory Failure-IV
126
Respiratory failure can manifest suddenly or gradually, characterized by a rapid decline in PaO2 and a rapid rise in PaCO2. This situation indicates a severe respiratory problem that may quickly become a life-threatening emergency. One of the early signs of hypoxemic Acute Respiratory Failure (ARF) is a change in mental status due to the brain's sensitivity to oxygen levels and changes in acid-base balance. Symptoms such as restlessness, confusion, and agitation suggest inadequate oxygen...
126


