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通过防止PD-1抑制,STAT5激活增强了结合接种的采用疗法

Aaron E Fan1,2, Hussein Sultan2,3, Takumi Kumai4

  • 1Division of Pediatrics, Neuro-Oncology Section, MD Anderson Cancer Center, Houston, Texas.

Molecular cancer therapeutics
|November 25, 2024
PubMed
概括

采用细胞疗法与类疫苗相结合,可以扩大抗原特异性T细胞. 具有构成性活跃STAT5 (CA-STAT5) 的工程T细胞通过减少疲劳来增强其抗瘤活性和持久性.

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