在患有口腔平细胞癌的患者中,低维他命症D:是否是发展这种新生病的危险因素?
A Maturana-Ramiìrez1, J Aitken-Saavedra, G Rojas-Zúñiga
1Department of Oral Pathology and Medicine Faculty of Dentistry, Universidad de Chile 8380492 Olivos 943, Independencia, Santiago, Chile amaturana@odontologia.uchile.cl.
Medicina oral, patologia oral y cirugia bucal
|November 25, 2024
概括
患有口腔状细胞癌 (OSCC) 的个人具有较低的维生素D (25(OH) D3) 水平. 这种缺陷可能与OSCC的发展有关,建议补充维生素D作为潜在的预防策略.
科学领域:
- 营养生物化学 营养生物化学
- 在瘤学瘤学.
- 公共卫生 公共卫生
背景情况:
- 维生素D缺乏 (维生素D缺乏症) 是一个越来越严重的公共卫生问题.
- 新出现的证据表明,维生素D状态与各种疾病之间存在潜在联系,包括口腔状细胞癌 (OSCC).
研究的目的:
- 为了比较有和没有OSCC的个体之间的血清25-基维生素D3 (25(OH) D3) 水平.
- 调查吸烟习惯对与OSCC相关的维生素D水平的影响.
主要方法:
- 一项多中心病例控制研究,涉及46名OSCC患者和65名对照.
- 用电化学发光来量化血清25(OH) D3水平.
- 统计分析包括曼-惠特尼和克鲁斯卡尔-瓦利斯试验,显著性设置在p <0.05.
主要成果:
- 观察到维生素D缺乏的高患病率,其中91%的参与者表现出某种程度的缺乏.
- 与对照组 (中位数为24.8 ng/ml) 相比,OSCC患者的血清25(OH) D3水平显著降低 (中位数为20.2 ng/ml) (p=0.002).
- 在非吸烟对照组和吸烟的OSCC患者之间发现了维生素D水平的显著差异 (p < 0.05).
结论:
- 较低的血清25(OH) D3水平与口腔状细胞癌 (OSCC) 有关.
- 这些发现表明,维生素D缺乏在OSCC发育中的潜在作用.
- 维生素D补充剂可能为OSCC的预防和治疗提供了一个有希望的策略.
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