与年龄相关的神经退行性疾病中混合神经病理的患病率:中国的一项基于社区的尸体解剖研究
Xiaoxi Wang1, Keqing Zhu2,3, Wei Wu4,5
1Department of Pathology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|November 25, 2024
概括
脑血管疾病 (CVD) 可能是中国混合神经病理的最早贡献者,比如初级与年龄相关的病 (PART) 和边缘主导的与年龄相关的TDP-43脑病 (LATE) 等疾病更早. 这项研究分析了1142个中国大脑样本,揭示了具有区域差异的普遍神经病理.
科学领域:
- 神经病理学神经病理学
- 神经退行性疾病 神经退行性疾病
- 公共卫生 公共卫生
背景情况:
- 关于中国混合神经病理的数据有限.
- 这项研究利用中国大脑银行样本解决了这一差距.
研究的目的:
- 分析大量中国人群中各种神经病理的患病率和相关性.
- 调查混合神经病理的潜在早期贡献者.
主要方法:
- 检查了来自6个中国脑库的1142个大脑.
- 标准化病理评估,严格的质量控制.
- 分析神经系统疾病的患病率和相关性.
主要成果:
- 主要与年龄相关的病 (PART,35%),临主导的与年龄相关的TDP-43脑病 (LATE,46%),与年龄相关的星病 (ARTAG,12%),阿尔茨海默病的神经病理变化 (ADNC,48%),莱维体病 (LBD,13%) 和脑血管疾病 (CVD,63%) 的高患病率.
- 神经病理常常与显著的区域差异同时发生.
- 脑血管疾病 (CVD) 成为潜在的早期贡献者.
结论:
- 像PART,LATE,ARTAG,ADNC,LBD和CVD这样的神经病理在中国普遍存在,与其他地区相比,随着年龄的增长而增加.
- 观察到疾病发病率的区域差异很大.
- 心血管疾病似乎先于其他神经病理,包括PART,LATE和ARTAG.
相关概念视频
Neural Regulation
39.1K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.1K
Alzheimer's Disease: Overview
448
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
448
Parkinson's Disease: Overview
482
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
482


