孕期糖尿病复杂的怀孕中胎儿心率分析:一个前性的多中心观察性研究
Sian Chivers1,2, Caroline Ovadia1,3, Tharni Vasavan1
1Department of Women's and Children's Health, King's College London, London, UK.
BJOG : an international journal of obstetrics and gynaecology
|November 25, 2024
概括
怀孕期糖尿病 (GDM) 与胎儿心率变化 (HRV) 和心率变化 (FHR) 有关. 这些变化表明对胎儿自主功能的潜在影响,通过非侵入性胎儿心电图检测到.
科学领域:
- 产科和妇科 产科和妇科
- 胎儿医学 胎儿医学
- 心脏病学 心脏病学
背景情况:
- 孕期糖尿病 (GDM) 是一种常见的妊娠并发症.
- 以前的研究表明GDM可能对胎儿心脏有影响,但非侵入性胎儿心电图 (ECG) 数据有限.
- 了解这些影响对于胎儿健康至关重要.
研究的目的:
- 调查GDM怀孕是否表现出与心律失常风险相关的胎儿心脏表型.
- 使用非侵入性腹部胎儿心电图来测量胎儿心率 (FHR) 和胎儿心率变化 (HRV).
主要方法:
- 一项前性观察性研究,在英国三所三级产科科室进行.
- 包括16岁以上的女性,有GDM或没有并发症的怀孕 (>20周怀孕).
- 使用MonicaAN24非侵入性腹部胎儿心电图监测器进行夜间记录,以计算FHR和HRV指标 (SDNN,RMSSD,PR,QRS,QT间隔).
主要成果:
- 分析了96名参与者.
- 在睡眠状态1F (12.56毫秒与8.58毫秒相比,p=0.01) 期间,在患有GDM的母亲的胎儿中观察到正常与正常间隔 (SDNN) 的标准偏差较高,HRV指标.
- 没有发现RMSSD或心脏时间间隔的显著差异;然而,HRV与BMI/HbA1c负相关,FHR与BMI/HbA1c正相关.
结论:
- 胎儿心率变化和胎儿心率变化与GDM有关.
- 这些变化可能源于自主功能在子宫内的变化.
- 非侵入性胎儿心电图可以检测在GDM怀孕中这些微妙的心脏表型变化.
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