在患有慢性便秘的儿童中评估含量
Abdurrahman Zarif Güney1, Güzide Doğan2, Ali Toprak1
1Department of Pediatrics, Faculty of Medicine, Bezmialem Vakıf University, İstanbul, Türkiye.
The Turkish journal of pediatrics
|November 25, 2024
概括
患有慢性便秘的儿童的血水平 (BLL) 比健康儿童高. 这表明暴露和便秘之间存在联系,强调了在受影响儿童中进行BLL测试的必要性.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
背景情况:
- 慢性便秘是一种常见的儿科问题,具有多因素的原因.
- 暴露是一种已知的神经毒素,但其在便秘等胃肠道疾病中的作用不太清楚.
- 评估患有便秘的儿童的负担对于确定潜在的环境贡献者至关重要.
研究的目的:
- 为了比较患有慢性便秘的儿童与健康对照者的血水平 (BLL) 和头发水平 (HLL).
- 调查暴露与儿童便秘病因之间的关联.
- 探索儿童群体中BLL和HLL之间的相关性.
主要方法:
- 一项病例控制研究涉及84名患有便秘的儿童和84名健康的对照,年龄在3-18岁之间.
- 通过全面的病史,体检和实验室测试,排除有机疾病.
- 使用标准化方法分析血液和头发样本以检测度.
主要成果:
- 与对照组 (1.61μg/dL) 相比,患有便秘的儿童的BLL显著增加 (3.66μg/dL).
- 几乎一半 (48.8%) 的便秘儿童超过了3.5μg/dL的参考BLL,而对照组只有4.8%.
- 两组之间没有观察到HLL的显著差异;BLL是一个比HLL更可靠的指标,HLL因性别和年龄而异.
结论:
- 血水平升高与儿童慢性便秘之间存在显著的关联.
- 医疗保健提供者应将暴露视为儿童便秘的潜在因素.
- 对于患有慢性便秘的儿童,可能需要进行例行BLL测试,以指导预防和干预策略.
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