探索免疫球蛋白A血管炎患者胃肠道参与的预测因素
Betül Öksel1, Nihal Şahin1, Hafize Emine Sönmez1
1Department of Pediatrics, Department of Pediatric Rheumatology, Faculty of Medicine, Kocaeli University, Kocaeli, Türkiye.
The Turkish journal of pediatrics
|November 25, 2024
概括
胃肠道 (GI) 参与免疫球蛋白A血管炎 (IgAV) 是常见的,并与炎症标志物升高有关. 系统性免疫炎症指数 (SII) 和系统性炎症反应指数 (SIRI) 可能有助于识别患有胃肠道并发症的患者.
科学领域:
- 儿科风湿病学 儿科风湿病学
- 儿科胃肠病学 儿科胃肠病学
- 系统性血管炎是什么?
背景情况:
- 免疫球蛋白A血管炎 (IgAV) 是儿童最常见的全身血管炎.
- 胃肠道 (GI) 症状发生在约50%的IgAV病例中.
- 了解胃肠道干预对于管理潜在并发症至关重要.
研究的目的:
- 分析IGAV患者的临床和实验室检测结果.
- 在IgAV中识别胃肠道并发症的潜在生物标志物.
- 评估系统性炎症指数在检测胃肠道干预方面的有用性.
主要方法:
- 对210名IgAV患者的临床和实验室数据的回顾性分析.
- 患者组之间的消化道干扰状况的比较.
- 统计分析以确定各种实验室参数和炎症指数的意义.
主要成果:
- 在210名患者中,有101名患者表现出胃肠道干扰,腹痛是最常见的症状.
- 升高的白细胞,中性细胞,单细胞和血小板数量,C反应蛋白,NLR,PLR,MLR,SII和SIRI与GI参与有显著的关联 (p<0.001).
- 对于SII,SIRI,NLR和MLR的确定的切线值表明中度灵敏度和高特异性用于识别GI参与.
结论:
- 胃肠道参与IgAV,虽然通常是自我限制的,但可能导致严重的后果.
- 系统性炎症指数,特别是SII和SIRI,显示出有前途的指标,用于识别IGAV患者的GI参与.
- 进一步的研究可能会完善这些指数用于早期检测和管理的使用.
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