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Updated: Jun 6, 2025

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发育性阅读障碍和发育性口吃的共同神经生物学基础:功能和结构MRI研究的元分析

Huan Ren^1,2, Yi Zhen Li^1,2, Hong-Yan Bi^1,2

¹Key Laboratory of Behavioral Science, Center for Brain Science and Learning Difficulties, Institute of Psychology, Chinese Academy of Sciences, Beijing, 100101, China.

International journal of clinical and health psychology : IJCHP

|November 25, 2024

概括

发育性阅读障碍症和持续发育性口吃有共同的脑部变化,特别是在左侧部和部区域. 这些发现表明,书面和口语语言障碍的共同神经支.

科学领域:

神经科学是一个神经科学.
认知科学认知科学
语言学的语言学.

背景情况:

发育性阅读障碍 (DD) 和持续发育性口吃 (PDS) 分别是普遍存在的书面和口语语言障碍.
这两种疾病都对个人的生活质量和学术/职业成功产生重大影响.
虽然在DD和PDS中已知大脑变化,但共享的神经基质仍然不清楚.

研究的目的:

系统地审查和元分析功能磁共振成像 (fMRI) 和基于voxel的形态测量 (VBM) 研究.
在发育性阅读障碍和持续发育性口吃中识别共享的功能和解剖学大脑变化.

主要方法:

基于任务的fMRI和VBM研究的系统审查和元分析.
与对照人群相比,对DD和PDS患者的功能和解剖学大脑变化的分析.
探索功能连接和大脑行为关系.

主要成果:

在DD和PDS中,fMRI揭示了左下部和部旋转的共享低活性.
儿童在多个左半球语言区域的活化减少,而成年人则在右半球和运动区域表现出补偿性过度活化.
在VBM中,左下额头回形中发现了灰质体积的减少,主要是在DD和PDS的儿童中.

结论:

这项研究突出显示了DD和PDS之间一致的大脑异常.
研究结果表明,共同的神经基质是书面和口语语言障碍的基础.
识别的跨诊断神经特征为语言障碍机制提供了新的见解.

关键词:

发育性阅读障碍症是一种发展性阅读障碍.功能性磁共振成像技术功能性磁共振成像技术进行元分析分析.持续的发育性口吃持续的发育性口吃基于voxel的形态测量方法

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