Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

525
Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
525
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

669
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
669
Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

756
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
756
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

964
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
964
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

1.6K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
1.6K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

AnalyzAIRR: A user-friendly guided workflow for AIRR data analysis.

Immunoinformatics (Amsterdam, Netherlands)·2026
Same author

Inferring Resource Competition in Microbial Communities from Time Series.

PRX life·2026
Same author

Design principles of the cytotoxic CD8<sup>+</sup> T cell response.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Contrasted modifications of IgM and IgT repertoires induced by high- and low-virulent infectious pancreatic necrosis virus strains in rainbow trout (<i>Oncorhynchus mykiss</i>).

Frontiers in immunology·2026
Same author

Paraplume: A fast and accurate antibody paratope prediction method provides insights into repertoire-scale binding dynamics.

PLoS computational biology·2026
Same author

Identification of a type 1 diabetes-associated T cell receptor repertoire signature from the human peripheral blood.

Science advances·2026

相关实验视频

Updated: Jun 6, 2025

Generation of Human Alloantigen-specific T Cells from Peripheral Blood
09:47

Generation of Human Alloantigen-specific T Cells from Peripheral Blood

Published on: November 21, 2014

13.0K

在开发人类T细胞谱的局部和全球变异性.

Giulio Isacchini1,2, Valentin Quiniou3,4, Pierre Barennes3,4

  • 1Max Planck Institute for Dynamics and Self-organization, Am Faßberg 17, 37077 Göttingen, Germany.

PRX life
|November 25, 2024
PubMed
概括

在T细胞受体 (TCR) 剧目中的个体差异在T细胞成熟过程中持续存在. 个体之间的这种变异性与一个人内不同类型T细胞的多样性一样重要.

更多相关视频

T and B Cell Receptor Immune Repertoire Analysis using Next-generation Sequencing
08:59

T and B Cell Receptor Immune Repertoire Analysis using Next-generation Sequencing

Published on: January 12, 2021

8.1K
Peptide:MHC Tetramer-based Enrichment of Epitope-specific T cells
13:58

Peptide:MHC Tetramer-based Enrichment of Epitope-specific T cells

Published on: October 22, 2012

17.9K

相关实验视频

Last Updated: Jun 6, 2025

Generation of Human Alloantigen-specific T Cells from Peripheral Blood
09:47

Generation of Human Alloantigen-specific T Cells from Peripheral Blood

Published on: November 21, 2014

13.0K
T and B Cell Receptor Immune Repertoire Analysis using Next-generation Sequencing
08:59

T and B Cell Receptor Immune Repertoire Analysis using Next-generation Sequencing

Published on: January 12, 2021

8.1K
Peptide:MHC Tetramer-based Enrichment of Epitope-specific T cells
13:58

Peptide:MHC Tetramer-based Enrichment of Epitope-specific T cells

Published on: October 22, 2012

17.9K

科学领域:

  • 免疫学 免疫学 免疫学
  • 基因组学就是基因组学.
  • 计算生物学 计算生物学

背景情况:

  • 适应性免疫依赖于具有多种T细胞受体 (TCRs) 的T细胞来识别病原体.
  • 在胸腺T细胞发育过程中产生和选择TCRs.
  • 了解TCR曲目多样性对于免疫反应研究和治疗开发至关重要.

研究的目的:

  • 在T细胞成熟阶段分析人类的TCR谱.
  • 量化TCR谱中的个人间和细胞间的变异性.
  • 调查本地和全球TCR曲目相似性之间的关系.

主要方法:

  • 从小细胞子集对人类TCR谱的分析.
  • 开发用于局部TCR序列相似性的距离度量.
  • 个人和T细胞类型之间的谱系变异性的比较.

主要成果:

  • 在整个T细胞成熟过程中,TCR谱的个体间的变异性保持不变.
  • 个体之间的变异性与个体内的细胞类型之间的变异性相似.
  • 全谱模型准确地预测了局部相似性网络,表明没有禁止的TCR序列.

结论:

  • TCR 剧集的多样性是由个体特定的重组和发展过程形成的.
  • 局部序列相似度与全球谱系特征相关,并提供细胞类型信息.
  • 这些发现有助于进一步了解适应性免疫系统的复杂性和T细胞分化.