患有埃勒斯-丹洛斯综合征和高移动性谱系障碍的患者的头痛障碍
Dwij Mehta1, Lucy Simmonds1, Alan J Hakim1,2
1Headache and Facial Pain Group, University College London (UCL), Queen Square Institute of Neurology and The National Hospital for Neurology and Neurosurgery, London, United Kingdom.
Frontiers in neurology
|November 25, 2024
概括
头痛在埃勒斯-丹洛斯综合征 (EDS) 和高移动性谱系障碍 (HSD) 中很常见. 早期诊断和量身定制的治疗对这些患者至关重要,考虑到潜在的并发症.
科学领域:
- 神经学 神经学
- 类风湿病学 类风湿病学
- 遗传学 遗传学 是一个
背景情况:
- 包括头痛在内的关节外症状在埃勒斯-丹洛斯综合征 (EDS) 和高移动性谱系障碍 (HSD) 中很普遍.
- 偏头痛和静止性头痛是有症状的关节多动性患者的显著表现.
- 这些情况与遗传性结合组织疾病 (HCTD) 有关,需要仔细考虑相关的病理.
研究的目的:
- 对患有关节超移动性相关疾病的患者的常见头痛疾病进行审查,重点关注EDS和HSD.
- 描述这些人群中头痛的不同临床表现.
- 提供推的管理策略的概述,并强调临床医生对并发性疾病的认识.
主要方法:
- 关于EDS和HSD中头痛疾病的文献综述.
- 对临床表现和相关病理的分析.
- 综合当前的管理策略和建议.
主要成果:
- 与普通人群相比,患有症状关节多动性的患者报告头痛的频率更高,发病时间更早.
- 静止性头痛可能表明底层的脊髓脑脊髓液泄漏,dysautonomia,或椎病理.
- 血管EDS和系统性表现需要对侵入性手术进行仔细的风险评估.
结论:
- 提高临床医生对EDS和HSD并发性疾病的认识,对于有效的头痛管理至关重要.
- 针对患者量身定制的多学科方法对于管理复杂病例至关重要.
- 需要进一步的研究,特别是对于像部部不稳定性这样的有争议的诊断.
相关概念视频
01:28Disorders of the Skeletal Muscle
879
The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
879
01:15Equilibrium and Balance
4.4K
The inner ear assumes dual functionalities of auditory perception and equilibrium maintenance. The vestibule is the organ responsible for balance. This organ contains mechanoreceptors, specifically hair cells, endowed with stereocilia, which aid in deciphering information regarding the position and motion of our heads. Two intrinsic components, the utricle and saccule, help perceive head position, while the semicircular canals track head movement. Neurological messages initiated in the...
4.4K
01:18Disorders of the Autonomic Nervous System
565
The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
Raynaud's disease, also known as Raynaud's...
Raynaud's disease, also known as Raynaud's...
565
01:24Disorders of Hemostasis
710
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
710
01:27Dissociative Disorders
32
Dissociative disorders represent complex psychological conditions characterized by disruptions in consciousness, memory, identity, or perception. These disruptions cause individuals to experience a disconnection from their thoughts, emotions, and memories. The phenomenon is not merely an occasional lapse in attention but a profound alteration in mental functioning that can severely impact daily life.
Dissociative Fugue
A hallmark feature of dissociative disorders is the dissociative fugue...
Dissociative Fugue
A hallmark feature of dissociative disorders is the dissociative fugue...
32
01:30Attention-Deficit/Hyperactivity Disorder
42
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
42