在当前和缓解抑郁症中心理生物学应激反应概况:以人为中心的多系统方法
Manuel Kuhn1,2, David C Steinberger1, Jason José Bendezú3
1Center for Depression, Anxiety, and Stress Research, McLean Hospital, Boston, Massachusetts.
Biological psychiatry global open science
|November 25, 2024
概括
患有严重抑郁症 (MDD) 的成年人的失调应激反应与精神病理有关. 识别不同的应激反应概况可以为提高性和降低疾病风险提供有针对性的干预措施.
科学领域:
- 心理神经内分泌学心理学
- 临床心理学 临床心理学
- 压力研究 压力研究
背景情况:
- 不调节的应激反应,包括情感和下丘脑-垂体-上腺 (HPA) 轴活动,与严重抑郁症 (MDD) 有关.
- 青少年研究将不和的应激反应形状与负面影响和精神病理风险联系起来.
- 这些发现的扩展到具有不同MDD风险和相关因素的成年人仍然不清楚.
研究的目的:
- 用以以人为中心的方法评估MDD和没有MDD的成年人心理生物学应激反应概况.
- 识别人体内不同的应激反应模式.
- 检查这些个人资料和临床特征之间的关联.
主要方法:
- 评估了119名目前或缓解MDD的未经药物治疗的成年人和对照者的样本.
- 多轨迹建模分析了积极影响,消极影响和唾液皮质醇 (CORT) 水平.
- 马斯特里赫特急性压力测试被用来引起应激反应.
主要成果:
- 确定了四种不同的应激反应概况:规范性 (26.9%),CORT过度反应/情感稳定 (14.3%),CORT过度活性/情感反应1 (37.8%),以及CORT过度活性/情感反应2 (21.0%).
- 非规范性个人资料与心理病理风险增加有关.
- 应激反应概况与临床状态,抑郁症严重程度,无情感,感知压力,童年逆境和幸福感有着连贯的关系.
结论:
- 在MDD和没有MDD的成年人中存在明显的心理生物学应激反应概况.
- 非典型的应激反应模式与更大的精神病理学有关.
- 了解个体应激反应概况可以指导量身定制的干预措施,以提高弹性和减少与MDD相关的问题.
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