辛提利马布加伦瓦提尼布与或没有放射治疗治疗晚期肝细胞癌与肺转移的肺转移
Chang Liu1,2, Weixing Jiang3, Juxian Sun1
1Department of Hepatic Surgery VI, Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, Shanghai, People's Republic of China.
Journal of hepatocellular carcinoma
|November 25, 2024
概括
将放射治疗添加到sintilimab和lenvatinib中,显著改善了肺转移性肝细胞癌 (HCC) 的结果. 这种组合疗法可提高HCC患者的生存率和应答率.
科学领域:
- 在瘤学瘤学.
- 医学研究 医学研究
背景情况:
- 肝细胞癌 (HCC) 与肺转移 (PM) 呈现出不良的预后.
- 对于具有PM的高级HCC存在有限的有效治疗选择.
研究的目的:
- 评估用于PM的HCC患者与sintilimab和lenvatinib结合放射治疗的疗效和安全性.
- 为了比较接受sintilimab加lenvatinib的患者与接受放射治疗加sintilimab和lenvatinib的患者之间的结果.
主要方法:
- 一项回顾性研究,涉及2020-2021年期间治疗的144名HCC患者.
- 患者接受了辛提利马布加伦瓦提尼布 (S+L) 或放射治疗加辛提利马布和伦瓦提尼布 (RT+S+L).
- 评估了无进展生存率 (PFS),总生存率 (OS),客观反应率 (ORR),疾病控制率 (DCR) 和与治疗相关的不良事件 (TRAE).
主要成果:
- 与S + L组相比,RT + S + L组表现出优异的OS (25与16个月) 和PFS (14与6个月) 与S + L组相比.
- 目标反应率 (ORR) 和疾病控制率 (DCR) 在RT+S+L组显著更高 (分别为61.5%与27.6%和94.9%与76.2%).
- 在RT+S+L组中常见的3/4级TRAE包括高血压,血小板数量下降,总 bilirubin升高和蛋白尿.
结论:
- 与sintilimab和lenvatinib结合的放射治疗是肺转移的HCC的有效治疗策略.
- 放射治疗在改善高级HCC的治疗结果方面发挥着至关重要的作用.
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