评估含有维生素D和微量元素的补充剂对中度至重度喘患者的影响
Mansoor Ahoon1, Reza Farid-Hosseini1, Hooman Tehrani2
1Allergy research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Reports of biochemistry & molecular biology
|November 25, 2024
概括
这项研究发现,维生素D补充剂与标准喘护理一起,在中度至重度喘患者中显著改善了肺功能和生活质量. 氧化应激也减少了,特别是在维生素D组.
科学领域:
- 免疫学 免疫学 免疫学
- 肺部病理学 肺部病理学
- 营养科学 营养科学
背景情况:
- 喘是全球流行的一种过敏性呼吸道疾病.
- 中度至重度的喘影响着全球相当多的患者.
- 研究营养干预措施对于控制喘至关重要.
研究的目的:
- 评估维生素D,叶酸,,和铜补充剂对中度至重度喘的影响.
- 评估接受补充剂的喘患者临床症状,肺功能和生物标志物的变化.
- 为了确定多维生素糖 (Asmavit) 与单独维生素D3在喘管理中的有效性.
主要方法:
- 一项随机临床试验,涉及70名中度至重度喘患者 (年龄大于6岁).
- 两个组每天接受阿斯玛维特糖或维生素D3滴剂,持续两个月,并接受标准喘治疗.
- 评估包括临床检查,免疫学和生物化学测试,以及干预前后的生活质量评估.
主要成果:
- 两组患者的肺功能,喘控制和生活质量均显著改善 (P<0.05).
- 血清和叶酸水平与治疗前喘严重程度相关.
- 维生素D补充剂导致氧化应激更大降低 (P<0.05) 和增加FEV1 (强迫呼吸量1秒).
结论:
- 作为标准喘治疗的一部分,维生素D补充剂可以有效地改善临床结果.
- 营养干预,特别是维生素D,可以提高中度至重度喘患者的生活质量.
- 对喘管理中的特定营养素作用的进一步研究是有必要的.
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