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Updated: Jun 6, 2025

Biochemical Purification and Proteomic Characterization of Amyloid Fibril Cores from the Brain
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Biochemical Purification and Proteomic Characterization of Amyloid Fibril Cores from the Brain

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聚合粉样蛋白资源:关于粉样蛋白类聚合的数据库的全面审查

Valentín Iglesias1, Jarosław Chilimoniuk1, Carlos Pintado-Grima2

  • 1Clinical Research Centre, Medical University of Białystok, Białystok, Poland.

Computational and structural biotechnology journal
|November 25, 2024
PubMed
概括

蛋白质聚合数据库跟踪实验数据,以改善蛋白质可溶性预测和生物治疗开发. 本综述对这些资源进行了调查,强调了它们的演变和与预测工具的共生.

关键词:
粉样蛋白是什么 粉样蛋白是什么生物信息学是一种生物信息学.生物治疗学 生物治疗学数据库数据库数据库是一个数据库.普里昂 (Prion) 是一个子.蛋白质聚合蛋白质的聚合.蛋白质的溶解性 蛋白质的溶解性

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Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
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