在多发性硬化症中扩大认知和疾病侵入性之间的联系
Aprille Gangi1, Sarah A Raskin1,2, Aaron P Turner3,4,5
1Neuroscience Program, Trinity College, Hartford, CT.
International journal of MS care
|November 25, 2024
概括
多发性硬化症 (MS) 的认知障碍影响日常生活. 客观的处理速度和主观的认知知觉都独立地预测MS患者的疾病侵入性.
科学领域:
- 神经学 神经学
- 心理学 心理学 心理学
- 康复 康复 康复 康复
背景情况:
- 认知障碍是多发性硬化症 (MS) 的重要因素,导致疾病侵入性.
- 之前的研究将客观认知措施与疾病侵入性联系起来,但主观感知和心理缓冲器仍未得到充分探索.
研究的目的:
- 调查客观处理速度和主观认知作为MS疾病侵入性的贡献者.
- 探索性作为潜在的调节者在认知和疾病侵入性之间的关系.
主要方法:
- 一项涉及112名多发性硬化症患者的横截面研究.
- 使用疾病侵入性评级表 (IIRS),符号数字模式测试 (SDMT),感知缺陷问卷 (PDQ) 和MS弹性表 (MSRS) 收集的数据.
- 进行了等级线性回归和调节分析.
主要成果:
- 主观认知 (PDQ) 和客观处理速度 (SDMT) 独立预测疾病侵入性 (IIRS).
- 弹性 (MSRS) 独立地促进了疾病侵入性,但没有缓解认知-侵入性关系.
- 在测试模型中没有发现适度的证据.
结论:
- 客观的处理速度和主观的认知感知独立地与MS的疾病侵入性有关.
- 考虑认知表现和自我感知对于理解MS中生活中断至关重要.
- 弹性可能在疾病侵入性中发挥作用,但不会缓冲认知影响.
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