相关实验视频

Updated: Jun 6, 2025

An Experimental Model of Myocardial Infarction for Studying Cardiac Repair and Remodeling in Knockout Mice

An Experimental Model of Myocardial Infarction for Studying Cardiac Repair and Remodeling in Knockout Mice

Published on: July 14, 2023

奥米克斯的分析显示,加勒-3是遗传性血管瘤中过敏炎症的潜在关键调节剂

Supriya D Mahajan¹, Ravikumar Aalinkeel¹, Jessica L Reynolds¹

¹Department of Medicine, Division of Allergy, Immunology & Rheumatology, Jacobs School of Medicine and Biomedical Sciences, Clinical Translational Research Center, University at Buffalo, Buffalo, NY.

The journal of allergy and clinical immunology. Global

|November 25, 2024

概括

这项研究使用多组学分析确定了遗传性血管 III 型 (HAE-III) 的新生物标志物. 加勒-3和其他蛋白质的水平增加表明免疫反应和HAE-III的潜在治疗点.

科学领域:

基因组学和蛋白质组学
免疫学免疫学免疫学
系统生物学系统生物学

背景情况:

遗传性血管 (HAE) 是一种罕见的遗传性疾病,由于布拉迪基宁的释放引起血管性.
HAE存在三种类型:I型 (C1-INH缺乏),II型 (功能障碍的C1-INH) 和III型 (正常的C1-INH功能).
了解HAE-III的发病性对于诊断和治疗至关重要.

研究的目的:

通过系统生物学来识别遗传性血管水III型 (HAE-III) 诊断的新生物标志物.
阐明HAE-III的潜在致病机制.

主要方法:

从HAE-III患者和健康对照组的血液样本进行多组学分析.
使用液体染色体质谱平台进行蛋白质,脂质,电解质和代谢物的分析.
使用MSFragger,LipiDex和Compound Discoverer进行识别和差异表达式分析.

主要成果:

发现了1647种新的基因,蛋白质和代谢物.
在HAE-III受试者中观察到显著增加的加勒-3,溶酶体α-葡萄糖酶,血小板因子4和血小板衍生的生生长因子亚单元A.
这些蛋白与免疫调节反应有关.

结论:

盖列-3在HAE-III中涉及氨基基细胞的招募和呼吸道炎症.
加勒-3可能会导致HAE-III的慢性炎症,纤维化和血管透性.
盖列-3是HAE-III的潜在治疗标.

关键词:

这是一种C1酶抑制剂 (C1-INH).多种组合的多种组合.过敏性炎症是一种过敏性炎症.生物标志物生物标志物盖莱克-3的使用方法遗传性血管 (HAE) 是一种代谢生物组的代谢生物组蛋白质组学蛋白质组学系统生物学系统生物学血管透性的血管透性

更多相关视频

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

相关概念视频

GPCRs Regulate Adenylyl Cylase Activity

GPCRs Regulate Adenylyl Cylase Activity

Some GPCRs transmit signals through adenylyl cyclase (AC), a transmembrane enzyme. AC helps synthesize second messenger cyclic adenosine monophosphate (cAMP). AC catalyzes cyclization reaction and converts ATP to cAMP by releasing a pyrophosphate. The pyrophosphate is further hydrolyzed to phosphate by the enzyme pyrophosphatase, which drives cAMP synthesis to completion. However, cAMP is rapidly degraded to 5′ AMP by the enzymes phosphodiesterase (PDE), preventing overstimulation of...

Proteoglycans

Proteoglycans

Glycans, a class of complex heterogeneous molecules, can be covalently attached to proteins to form glycosylated proteins that regulate various physiological and pathological processes. Glycosylated proteins or glycoproteins comprise N-linked and O-linked oligosaccharides. O-glycosylation is the most common type of protein glycosylation. Here, glycans attach to the oxygen atom of the hydroxyl groups of Serine or Threonine residues. O-linked glycosylation occurs later in protein processing,...

Genome-wide Association Studies-GWAS

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...