相关实验视频
Updated: Jun 6, 2025
04:39
Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
1.6K
在怀孕早期的甲状腺自身免疫患者的血清代谢物概况
Zhaoying Chen1, Zhenyu Lin2, Yiyang Gao1
1Department of Endocrinology and Metabolism, The First Hospital of China Medical University, Shenyang, Liaoning, China.
PeerJ
|November 25, 2024
概括
这项研究在患有甲状腺自身免疫 (TAI) 的孕妇中确定了92种不同血清代谢物,将特定的代谢物与较低的出生体重和贫血等不良妊娠结果联系起来. 这些发现支持在TAI患者中早期查代谢异常.
科学领域:
- 内分泌学 在内分泌学.
- 代谢学 代谢学 代谢学
- 生殖医学 生殖医学
背景情况:
- 有限的研究存在于甲状腺自身免疫 (TAI) 的孕妇的血清代谢物概况.
- 在TAI中了解怀孕期间的代谢变化对于孕产妇和胎儿的健康至关重要.
- 怀孕早期的代谢变化可能会影响怀孕的结果.
研究的目的:
- 与健康对照人群相比,在患有TAI的孕妇中识别不同血清代谢物.
- 评估已识别的代谢物与怀孕结果之间的关系.
- 探索潜在的生物标志物来预测TAI怀孕中的不良结果.
主要方法:
- 使用液态染色体质谱法 (LC-MS) 对血清代谢物概况进行比较分析.
- 包括26名TAI和30名健康对照 (HC) 的孕妇.
- 统计分析包括最小绝对收缩和选择操作员 (LASSO) 回归和相关性分析.
主要成果:
- 确定了92种不同的代谢物 (50种上调,42种下调) 和四种丰富的KEGG通路.
- 在TAI患者的新生儿中观察到较低的出生体重 (P = 0.007).
- 与贫血,尿酸,禁食血糖和出生体重相关的特定代谢物;与甲状腺自身抗体相关的14种代谢物.
结论:
- 血清代谢物分析可以揭示TAI怀孕的显著差异.
- 某些代谢产物在TAI中显示出潜在的预测性生物标志物,用于预测妊娠不良结果.
- 早期查血清代谢物可能有助于在怀孕期间管理TAI.
相关概念视频
01:20Synthesis and Regulation of Thyroid Hormones
4.2K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.2K
01:18Functions of Thyroid Hormones
2.5K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
2.5K
01:22Development of Immunocompetence
288
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
288