在住院患者中,登革热和SARS-CoV-2共传播和重叠感染
Thayza M I L Santos1, Alice F Versiani2, Guilherme R F Campos1
1Laboratório de Pesquisa em Virologia, Departamento de Doenças Infecciosas e Parasitárias, Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto, Brazil.
Frontiers in cellular and infection microbiology
|November 25, 2024
概括
巴西的登革热病毒 (DENV) 和SARS-CoV-2的同时感染导致了严重的临床结果,包括高住院和死亡率. 区分这些感染对于热带地区有效的患者管理至关重要.
科学领域:
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- 冠状病毒疾病 (COVID-19) 和登革热病毒 (DENV) 构成了全球重大健康挑战.
- 像巴西这样的热带地区面临着两种疾病的同时风险.
- 在SARS-CoV-2和DENV之间的共感染的影响仍然不太清楚.
研究的目的:
- 为了调查巴西COVID-19患者中DENV的血清流行率.
- 分析患有同时感染的患者的临床结果和免疫反应.
- 评估SARS-CoV-2患者中初级和二级登革热感染之间的临床表现的差异.
主要方法:
- 在来自COVID-19患者的400个血清样本上使用了血清和分子分析.
- 使用ELISA和FRNT80检测DENV IgM,NS1和中和抗体.
- 分析了细胞因子水平 (IL-10,TNF-α,IL-1β) 和临床数据.
主要成果:
- 6%的COVID-19患者显示DENV IgM阳性,62.5%具有中和抗体,表明最近或过去的感染.
- 同时感染的患者显示IL-10,TNF-α和IL-1β水平升高.
- 在SARS-CoV-2/DENV同时感染的患者中观察到高住院率 (94.9%) 和死亡率 (50%).
- 患有SARS-CoV-2的二次登革热患者有增加的呼吸困难和更长的ICU停留时间.
- 患有SARS-CoV-2的初级登革热患者更有可能出现发烧和咳.
结论:
- 区分SARS-CoV-2和DENV感染对于热带国家患者管理至关重要.
- 同时感染显著恶化了临床结果,增加了死亡率和对呼吸系统支持的需求.
- 在SARS-CoV-2感染的背景下,了解初级与二级登革热的影响临床表现和管理策略.
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