库尔库含有黄素的长循环脂质体改善了2型糖尿病小鼠的胰岛素抵抗
Kang-Xin Li1, Hui Yuan1, Jing Zhang2,3
1Department of Endocrinology, The Fifth Affiliated Hospital, Southern Medical University, Guangzhou, People's Republic of China.
International journal of nanomedicine
|November 25, 2024
概括
长循环的黄素载入脂质体 (CUR-LPs) 有效地治疗小鼠2型糖尿病. 通过减少肝炎和氧化应激,CUR-LPs可以改善葡萄糖代谢和胰岛素抵抗.
科学领域:
- 药理学 药理学是指药理学的学科.
- 生物技术是生物技术.
- 纳米医学是一种纳米医学.
背景情况:
- 2型糖尿病 (T2DM) 涉及胰岛素抵抗,高血糖和炎症,氧化应激加剧了进展.
- 黄素 (CUR) 具有对T2DM有益的抗炎,抗氧化和胰岛素敏感性,但其治疗用途受到溶解性和生物可用性差的阻碍.
研究的目的:
- 开发长循环的黄素载脂体 (CUR-LPs),以提高黄素的稳定性,溶解性和循环时间.
- 评估CUR-LPs在T2DM小鼠模型中改善胰岛素耐药性的疗效.
主要方法:
- 准备并对物理性质,封装效率和药物载荷能力进行了CUR-LP的描述.
- 在实验室中评估了细胞的活力. 在体内研究涉及高脂肪饮食/链毒素诱导的T2DM小鼠模型,接受CUR-LPs治疗.
- 肝炎炎症 (TNF-α,IL-6) 和氧化应激 (GSH,SOD) 的关键标志物被量化.
主要成果:
- CUR-LPs显示球形形态,最佳颗粒大小,高封装效率 (99.2%) 和药物载荷能力 (1.63%).
- 与T2DM小鼠的自由CUR相比,CUR-LPs显著改善了血糖和胰岛素水平.
- 用CUR-LPs治疗导致肝炎的减少,增强抗氧化能力 (GSH,SOD) 和减弱肝损伤.
结论:
- 在T2DM小鼠模型中,CUR-LPs有效地改善了葡萄糖代谢和胰岛素抵抗.
- CUR-LP的治疗益处很可能归因于其减轻肝炎和减少氧化应激的能力.
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