状细胞病患者的维生素D缺乏和血管缩:一项回顾性队列研究
Abdullah J Tammas1, Luluh B Albehlal2, Fahad Alabbas1
1Pediatric Hematology/Oncology, Prince Sultan Medical Military City, Riyadh, SAU.
Cureus
|November 25, 2024
概括
维生素D缺乏 (VDD) 在状细胞病 (SCD) 患者中显著增加了无血管亡 (AVN) 的风险. 这项研究发现VDD是AVN的独立风险因素,强调了对维生素D补充剂的进一步研究的需要.
科学领域:
- 血液学 血液学 血液学
- 整形外科 整形外科 整形外科
- 内分泌学 在内分泌学.
背景情况:
- 状细胞疾病 (SCD) 是一种复杂的遗传性血液疾病,具有多系统性并发症.
- 血管性亡 (AVN) 是SCD患者常见和致残的并发症.
- 维生素D缺乏 (VDD) 在SCD患者中很普遍,但其在AVN发展中的作用尚未得到充分研究.
研究的目的:
- 在SCD患者中调查VDD和AVN之间的关联.
- 为了确定AVN呈现的模式,风险因素,诊断和治疗在这个队列.
- 确定VDD是否是SCD中AVN的独立风险因素.
主要方法:
- 从2020年1月到2022年12月,对711名证实患有VDD的SCD患者进行回顾性队列研究.
- 纳入标准:证实了SCD和VDD测试;排除:骨髓移植接受者.
- 统计分析包括千平方测试和多变量后勤回归来评估关联和对混因素的控制.
主要成果:
- 在17.9%的队列中诊断出AVN,平均年龄为30.9岁.
- 慢性关节疼痛是主要症状 (>95%),部是受影响最多的关节 (86%).
- 患有VDD的SCD患者患有AVN的几率高9.79倍 (OR9.79;95%CI:5.25-18.26),独立于其他风险因素,如频繁的血管闭塞危机,年龄较大,急性胸部综合征和高BMI.
结论:
- 在研究的SCD队列中,AVN是致病的重要原因,通常在晚期 (III/IV) 诊断出来.
- 维生素D缺乏被认为是状细胞疾病中AVN的独立风险因素.
- 需要进一步的随机对照试验来评估维生素D补充剂在预防SCD患者AVN的疗效.
关键词:
一个成熟的成年人.没有血管亡.在前面的路上.孩子们的孩子们的孩子们的孩子们.沙特阿拉伯 沙特阿拉伯在SCD中,SCD是SCD.状细胞疾病是一种状细胞疾病.这就是VDDVDD.维生素D 缺乏症 维生素D 缺乏症更多相关视频
06:47Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells
Published on: May 4, 2018
9.3K
08:23Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry
Published on: November 5, 2019
9.8K
相关概念视频
01:25Role of Vitamins in Maintaining Bone Health
3.2K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
3.2K
01:29Bone Disorders
3.4K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.4K
01:30Vitamins
563
Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced...
563
01:29Blood and Nerve Supply to the Bones
10.7K
Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
10.7K
01:09Changes in the Appendicular Skeleton with Age
1.8K
The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
1.8K