评估白病患者的Helicobacter pylori和小肠细菌过度生长的情况
Jessie M Nelson1, Jason M Rizzo2, Rachel K Greene1
1Dermatology, University of Michigan, Ann Arbor, USA.
Cureus
|November 25, 2024
概括
小肠细菌过度生长 (SIBO) 在病患者中比一般人群中更为常见. 这一发现表明SIBO和疹之间存在潜在联系,为治疗提供了新的途径.
科学领域:
- 皮肤病学 皮肤病学
- 胃肠病学 胃肠病学
- 微生物学 微生物学
背景情况:
- 系统性免疫异常可能会影响粉红的发展.
- 以前的研究表明,粉红病与细菌过度生长之间存在联系,包括Helicobacter pylori (H. pylori) 和小肠细菌过度生长 (SIBO),但研究结果不一致.
- 不一致的测试方法和混因素导致现有文献中的差异.
研究的目的:
- 为了调查H. pylori和SIBO在粉红病患者中的患病率.
- 为了控制H. pylori和SIBO流行率的评估中的潜在混因素.
- 为了探索SIBO和粉红病之间的关联.
主要方法:
- 一项涉及患者的横截面研究,该研究涉及患有斑点斑点性或红色斑块性疹性粉红病的患者.
- 排除具有先前存在的胃肠道疾病,胃肠道手术,自身免疫性疾病,免疫抑制或重大并发症的参与者.
- 针对特定药物的标准化洗期和粉红病/胃肠道健康的评估.
- 使用13C尿素呼吸和葡萄糖呼吸测试分别检测H. pylori和SIBO.
主要成果:
- 在27名粉红患者中,14.8%的H. pylori和33.3%的SIBO检测呈阳性.
- 与一般人群相比,H. pylori的流行率在粉红队列中较低 (p=0.02).
- 与一般人群相比,SIBO患病率在粉红队列中明显高 (p<0.001).
- 在人口统计,粉红病严重程度或胃肠道症状与H. pylori或SIBO阳性之间没有发现显著的关联.
结论:
- 在控制混因子后,SIBO在疹患者中更为普遍,这表明存在潜在的关联.
- SIBO和粉红病理生理学的确切关系尚不清楚;SIBO可能导致粉红,或者两者都可能是免疫系统异常的结果.
- 观察到的关联需要进一步调查,并可能为粉红病提供新的治疗点.
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