用胺和布德索尼德进行雾化对在全身麻醉下进行选择性手术的患者手术后喉痛的影响:一项随机对照比较临床研究
Sanya Varma1, Subha Teresa Jose Vazhakalayil1
1Anesthesiology, Dr. D. Y. Patil Medical College, Hospital & Research Centre, Dr. D. Y. Patil Vidyapeeth (Deemed to be University), Pune, IND.
Cureus
|November 25, 2024
概括
在手术前用胺或布德索尼德进行雾化,可以有效地减少输管后的术后喉痛. 由于像幻觉这样的副作用较少,布德索尼德是首选的.
科学领域:
- 麻醉学 麻醉学
- 药理学 药理学是指药理学的学科.
背景情况:
- 手术后喉疼痛 (POST) 是内内输管术后的一个常见并发症.
- 炎症和喉创伤是POST的主要原因.
- 目前的预防策略涉及各种抗炎药物.
研究的目的:
- 评估使用胺和布德索尼德进行手术前雾化在减少POST的有效性.
- 为了比较这两种药物的有效性,以尽量减少随着时间的推移而引起的喉不适.
主要方法:
- 一项前性,双盲,随机对照试验,涉及100名接受选择性手术的成年患者.
- 患者在手术前接受了 nebulized ketamine 或 budesonide 两种药物.
- 在多个时间点使用四分级来评估术后喉痛;监测血液动力学参数.
主要成果:
- 胺和布德索尼德都降低了POST的发生率和严重程度.
- 喉疼痛的发生率在输出管后立即最高,并在24小时内下降.
- 胺组报告的幻觉发病率高于布德索尼德组.
结论:
- 雾化胺和布德索尼德在缓解术后喉疼痛方面是有效的.
- 布索尼德表现出有利的安全性,并发症较少,使其成为潜在的首选选择.
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