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双方法精确的H₂O₂调节,以平衡与瘤相关的巨细胞再极化和免疫性瘤细胞死亡诱导

Yan Zhao¹, Weiheng Kong¹, Jianqing Zhu²

¹College of Chemistry and Chemical Engineering, Qufu Normal University Qufu Shandong 273165 China qufengli@him.cas.cn.

Chemical science

|November 25, 2024

概括

这项研究介绍了ZnO2-ATM,一种新型纳米辅助剂,通过调节过氧化 (H2O2) 水平来协调与瘤相关的巨细胞 (TAM) 再极化和免疫细胞死亡 (ICD),以增强癌症免疫疗法.

科学领域:

生物医学工程生物医学工程
免疫学免疫学免疫学
材料科学材料科学材料科学

背景情况:

同时与瘤相关的巨细胞 (TAM) 反极化和免疫性瘤细胞死亡 (ICD) 诱导对于有效的癌症免疫疗法至关重要.
目前刺激耐受性的局限性阻碍了这两个过程的协调实施.

研究的目的:

开发一种新的策略来协调TAM再极化和ICD诱导.
为了验证氧化 (H2O2) 介导的协同抗瘤免疫反应的监管方法.

主要方法:

构建一个双模态响应调节器,ZnO2-ATM (ATM:3-amino-1,2,4-triazole),作为一种免疫辅助剂.
使用ZnO2-ATM来实现协同响应的H2O2生产,以实现协调的治疗效果.

主要成果:

ZnO2-ATM有效地通过H2O2生产将免疫抑制的M2 TAMs重新极化为M1表型.
由ZnO2-ATM产生的H2O2诱导瘤细胞缩,并促进损伤相关分子模式 (DAMP) 释放,引起ICD.
对TAM再极化和ICD的协调诱导产生了强大的抗瘤免疫效应.

结论:

介于H2O2的调节提供了一种可行的策略,可以实现同时实现TAM再极化和ICD诱导.
开发的ZnO2-ATM纳米辅助剂为推进癌症免疫疗法范式提供了一个有前途的新工具.

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Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.