基于正确合成的聚乙烯 (聚氨) 作为生物医学领域潜在的药物输送载体的希夫基交联基基:设计和表征
Roberta Pappalardo1,2, Monica Boffito1, Claudio Cassino3
1Department of Mechanical and Aerospace Engineering, Politecnico di Torino, 10129 Turin, Italy.
ACS omega
|November 25, 2024
概括
新的聚乙 (聚乙) 形成了适应pH的基,用于药物输送. 这些可注射,自我愈合的材料在生理条件下提供持续释放和稳定性.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 药物输送系统 药物输送系统
背景情况:
- 在现场形成的水凝由于其生理稳定性,可注射性,自我愈合性和pH响应性而吸引药物输送.
- 希夫基化学为创建这种先进的水凝系统提供了一个多功能平台.
研究的目的:
- 设计和描述基于聚乙烯糖醇的新型聚乙尿 (PEUs) 用于in situ水凝形成.
- 评估开发的水凝的物理化学,质和药物释放性质.
主要方法:
- 合成一种具有主要氨基基群的高分子量PEU (SHE3350) 和一种具有化末端群的低分子量PEU (AHE1500).
- 通过混合SHE3350和AHE1500的水溶液形成水凝.
- 使用NMR光谱,风病学,胀研究和药物释放试验进行表征.
主要成果:
- 成功形成了具有高抗应变性和膨胀能力的希夫基交联液凝 (湿物重量增加了270%).
- 证明了pH值依赖的行为:在pH值5时增强吸收导致溶解,在pH值9时吸收减少.
- 一种模型药物 (FITC-dextran) 在17天内持续释放,具有pH触发释放特征.
结论:
- 基于PEU的工程水凝在药物输送方面表现出有希望的特性,包括可注射性和自我愈合性.
- 它们的pH反应性允许控制药物释放,使它们适合各种治疗应用.
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