从未加的中控制输送凯托可纳,一种抗真菌剂,采用层次技术
Hadil Faris Al-Otaibi1, Aishah Hassan Alharthi1, Aseel Esmail Alshonqeeti1
1Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah Bint Abdulrahman University, Riyadh 11671, Saudi Arabia.
ACS omega
|November 25, 2024
概括
一层一层 (LbL) 技术有效地提供可纳来预防真菌假肢关节感染 (PJI). 这种方法显示了药物释放的延长和炎症的减少,改善了关节置换手术患者的结果.
科学领域:
- 生物材料工程 生物材料工程
- 传染性疾病 传染性疾病
- 药物输送系统 药物输送系统
背景情况:
- 假肢关节感染 (PJI) 在关节置换手术中构成了重大挑战.
- 菌PJIs需要有效的预防和治疗策略.
- 目前的治疗方法可能在药物释放和疗效方面存在局限性.
研究的目的:
- 为了评估一层一层 (LbL) 技术的有效性,以提供可纳.
- 评估LbL涂层植入物在预防真菌PJIs方面的潜力.
- 为了研究药物释放动力学和LbL涂层的生物影响.
主要方法:
- 使用层层组装技术 (LbL) 涂层基板.
- 将可纳纳入LbL膜,以持续释放药物.
- 进行了体外和体内研究,以评估抗真菌疗效和炎症反应.
主要成果:
- 在体外 (>20天) 和体内 (60天) 长时间释放基托可纳.
- 在手术后14天的研究小组中观察到炎症减少的速度更快,并发症更少.
- LbL涂层对细胞活力产生了积极的影响,表明生物相容性.
结论:
- LbL技术是一种有前途的方法,可以提供可纳来预防真菌PJIs.
- LbL涂层提供了一种可扩展和有效的方法,用于增强关节置换中的预防策略.
- 需要进行进一步的研究,利用LbL技术探索各种抗真菌剂.
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