素和素检测对长期中耳炎与输液检测的影响
Zeqi Zhao1,2, Zhengzhong Han3, Yudi Shao1,2
1Department of Otorhinolaryngology-Head and Neck Surgery, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu Province, 221002, China.
Heliyon
|November 25, 2024
概括
中耳液中的素之类的喉喉反流 (LPR) 酶与长期中耳炎与溢出 (COME) 有关. 抑制酸的治疗减少了COME的复发,这表明了新的治疗方法.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 胃肠病学 胃肠病学
- 儿科 儿科 儿科
背景情况:
- 慢性中耳炎与溢出 (COME) 是导致听力损失的常见原因.
- 喉回流 (LPR) 是一个未被认可的因素在COME管理.
- 在中耳溢出 (MEE) 中识别反流标志物可能会改善治疗策略.
研究的目的:
- 在COME患者的MEE中检测出素和素.
- 为了评估抑制酸性治疗 (AST) 对 COME 复发的疗效.
- 探索素在MEE中对COME管理的作用.
主要方法:
- 对素和素度的MEE分析.
- 在AST和非AST组之间对COME复发率的比较.
- 接受AST的患者的未来随访.
主要成果:
- 在COME患者的MEE中检测到素和素.
- 在 AST 组中,一年内 COME 的复发率明显低于 AST 组.
- 在MEE中检测素可以识别受益于AST的患者.
结论:
- MEE中的素是COME中的LPR的潜在生物标志物.
- 抑制酸的治疗有效地减少了COME复发的发生.
- 对素阳性COME患者推AST可以预防OME复发.
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