接受免疫检查点抑制剂的患者心脏热素升高:来自前性研究的数据
Pieter F van den Berg1, Valentina Bracun1, Michel Noordman2
1Department of Cardiology, University Medical Center Groningen, Groningen, the Netherlands.
在接受免疫检查点抑制剂 (ICI) 的癌症患者中,高灵敏度托罗素T (hs-TnT) 的显著升高经常发生. 这些hs-TnT变化可能并不总是表明ICI心肌炎,突出诊断复杂性.
科学领域:
- 心脏病学 心脏病学
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 免疫检查点抑制剂 (ICI) 是重要的癌症治疗方法,但可能导致与免疫相关的不良事件.
- ICI心肌炎是一种严重的不良事件,由于早期症状和生物标志物的作用不清楚,因此难以诊断.
- 在ICI心肌炎诊断中,高灵敏度托罗素T (hs-TnT) 轨迹的意义仍然不确定.
研究的目的:
- 在接受ICI治疗的癌症患者中分析hs-TnT动力学.
- 为了确定ICI心肌炎发展的预测生物标志物.
主要方法:
- 在接受ICI治疗的164名患者中进行了前性,观察性,单中心研究.
- 收集患者病史,人口统计,临床特征和生存数据.
- 分析了hs-TnT升高 (≥14 ng/L) 和显著的hs-TnT升高 (≥28 ng/L) 与ICI心肌炎之间的关联.
主要成果:
- 16%的患者 (26/164) 显示显著的hs-TnT升高;5% (8/164) 发生了ICI心肌炎.
- 大多数ICI心肌炎病例 (69%) 的确诊不确定;38%缺乏心脏症状.
- 在ICI心肌炎患者中,hs-TnT的升高高于无症状患者.
结论:
- 在ICI患者中,显著的hs-TnT升高比以前认为的更为常见.
- 在ICI患者中hs-TnT水平升高通常无症状,并不总是意味着心肌炎.
- 需要进一步的研究来澄清hs-TnT在ICI心肌炎的诊断效用.
更多相关视频
14:03High-Throughput Cardiotoxicity Screening Using Mature Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Monolayers
Published on: March 24, 2023
04:41Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease
Published on: July 3, 2018
相关概念视频
Blood Studies for Cardiovascular System I: Cardiac Biomarkers
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
Myocarditis II: Clinical features and Diagnostic Tests
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
Myocarditis III: Medical Management
Imaging Studies for Cardiovascular System I:Echocardiography
Indications: Echocardiography is utilized to diagnose heart failure, valve disorders, and myocardial infarction. It also assesses cardiac structures' size, shape, and motion,...
Imaging Studies for Cardiovascular System V: CT
