相关实验视频

Updated: Jun 6, 2025

Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model

Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model

Published on: June 18, 2021

单一的基底水库尿基酶玻尿酸可以帮助预防脑下下垂体出血的后果吗?

Vicente Vanaclocha¹, Juan-Manuel Herrera², Marlon Rivera-Paz²

¹University of Valencia, Valencia, Spain.

|November 25, 2024

概括

在动脉瘤剪切过程中,单次玻尿酸水性尿基酶的使用有效地减少了血管,死亡率和CSF转移. 这种治疗改善了患者的治疗结果,但没有增加出血风险.

科学领域:

神经外科神经外科
血管神经学血管神经学
干预性神经放射学干预性神经放射学

背景情况:

动脉瘤下arachnoid出血 (aSAH) 治疗演变为内血管选择.
尿素激酶和高高酶 (rtPA) 历史上对凝块溶解有效,减少血管并改善结果.
最近人们对血栓溶解剂在aSAH管理中的兴趣重新浮现.

研究的目的:

为了评估单一玻尿酸体尿基酶在减少血管的疗效.
评估对神经系统缺陷,死亡率和CSF转移率的影响.
确定从这种干预中获益最多的患者子组.

主要方法:

对415名患有囊性动脉瘤的患者的回顾性分析 (2017年1月至2019年12月).
患者被分为六个治疗组:没有治疗,EVD,内血管,剪切,剪切 + 尿素酶,偶然.
所有患者的随访持续时间都超过了一年.

主要成果:

与费舍尔等级≥3SAH的内血管治疗相比,与同时使用水泌尿酶进行手术剪切显示,血管,CSF转移和死亡率较低.
尿素酶组在出院和6个月和12个月的随访期间获得了更高的格拉斯哥结局量表扩展 (GOSE) 评分.
随着尿酶的使用,没有观察到内出血或全身纤维解质的显著增加.

结论:

在动脉瘤剪切过程中,单一玻尿酸水性尿动酶是一种安全有效的辅助疗法.
这种方法可以减少血管,死亡率,以及需要永久转移CSF的需要.
这种益处在患有更高费舍尔级子关节出血的患者中更为明显.

关键词:

动脉瘤是一个动脉瘤.大脑血管脑血管延迟缺血性神经系统缺陷纤维溶解药物疗法纤维溶解药物治疗内纤维化纤维解.甲状腺下下垂体出血

更多相关视频

Minimally Invasive Endoscopic Intracerebral Hemorrhage Evacuation

Minimally Invasive Endoscopic Intracerebral Hemorrhage Evacuation

Published on: October 15, 2021

Double Direct Injection of Blood into the Cisterna Magna as a Model of Subarachnoid Hemorrhage

Double Direct Injection of Blood into the Cisterna Magna as a Model of Subarachnoid Hemorrhage

Published on: August 30, 2020

相关概念视频

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...

Depolarizing Blockers: Pharmocokinetics

Depolarizing Blockers: Pharmocokinetics

Depolarizing blockers are administered through intravenous injection. Succinylcholine is the most common choice of depolarizing blockers in emergency clinical practices. Although they have a rapid onset, they readily diffuse away from the motor end plate into the extracellular fluid. They are metabolized by enzymes such as liver butyrylcholinesterase and plasma pseudocholinesterases. This produces a short duration of action, typically 5-10 minutes long, unlike nondepolarizing blockers, which...